Publications by authors named "Yukiko Ochiai"
Article Synopsis
- Dopamine-deficient mice show increased activity that may stem from reduced muscarinic signaling in the brain.*
- In these mice, the density of the M2 muscarinic acetylcholine receptor is decreased in the cortex, potentially impacting acetylcholine levels.*
- Treatments with specific receptor agonists, like xanomeline and arecaidine propargyl ester tosylate, help reduce hyperactivity in these dopamine-deficient mice, indicating the role of certain muscarinic receptors in managing this behavior.*
Article Synopsis
- * Research on dopamine-deficient mice indicated that drugs like quetiapine and donepezil can reduce hyperactivity, suggesting a potential method to study psychiatric symptoms tied to dopamine deficiency.
- * The study revealed that quetiapine helps decrease hyperactivity in these mice potentially via serotonin (5-HT) receptor activation, pointing to the importance of 5-HT receptors in addressing psychiatric symptoms related to dopamine deficiency.
We report a case of Broca's aphasia in a left-handed patient with a right brain infarction. The patient's speech is consistent with a particular type of aphemia, that is, without vocalization except for a few phonemes or words. The patient presented with aphonia in an early stage.
View Article and Find Full Text PDFA 59-year-old woman with small-cell lung carcinoma achieved tumor disappearance after cisplatin-based chemotherapy (CBC) and radiation treatment but subsequently experienced right hemiparesis and aphasia. Brain magnetic resonance imaging revealed a left middle cerebral artery territory acute infarction and left internal carotid artery occlusion. Ultrasonography revealed a mobile thrombus in the left common and internal carotid arteries, and contrast computed tomography revealed a mural thrombus in the ascending aorta.
View Article and Find Full Text PDFDopamine is involved in many important brain functions, including voluntary motor movement. Dysfunction of the dopaminergic system can induce motor impairments, including Parkinson's disease. We previously found that dopamine-deficient (DD) mice became hyperactive in a novel environment 72 h after the last injection of L-3,4-dihydroxyphenylalanine (L-DOPA) when dopamine was almost completely depleted.
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