Publications by authors named "Yukiko Ochiai"

Article Synopsis
  • Dopamine-deficient mice show increased activity that may stem from reduced muscarinic signaling in the brain.*
  • In these mice, the density of the M2 muscarinic acetylcholine receptor is decreased in the cortex, potentially impacting acetylcholine levels.*
  • Treatments with specific receptor agonists, like xanomeline and arecaidine propargyl ester tosylate, help reduce hyperactivity in these dopamine-deficient mice, indicating the role of certain muscarinic receptors in managing this behavior.*
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Article Synopsis
  • * Research on dopamine-deficient mice indicated that drugs like quetiapine and donepezil can reduce hyperactivity, suggesting a potential method to study psychiatric symptoms tied to dopamine deficiency.
  • * The study revealed that quetiapine helps decrease hyperactivity in these mice potentially via serotonin (5-HT) receptor activation, pointing to the importance of 5-HT receptors in addressing psychiatric symptoms related to dopamine deficiency.
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We report a case of Broca's aphasia in a left-handed patient with a right brain infarction. The patient's speech is consistent with a particular type of aphemia, that is, without vocalization except for a few phonemes or words. The patient presented with aphonia in an early stage.

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A 59-year-old woman with small-cell lung carcinoma achieved tumor disappearance after cisplatin-based chemotherapy (CBC) and radiation treatment but subsequently experienced right hemiparesis and aphasia. Brain magnetic resonance imaging revealed a left middle cerebral artery territory acute infarction and left internal carotid artery occlusion. Ultrasonography revealed a mobile thrombus in the left common and internal carotid arteries, and contrast computed tomography revealed a mural thrombus in the ascending aorta.

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Dopamine is involved in many important brain functions, including voluntary motor movement. Dysfunction of the dopaminergic system can induce motor impairments, including Parkinson's disease. We previously found that dopamine-deficient (DD) mice became hyperactive in a novel environment 72 h after the last injection of L-3,4-dihydroxyphenylalanine (L-DOPA) when dopamine was almost completely depleted.

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