HMGB1 attenuates anti-metastatic defense of the lymph nodes in colorectal cancer.

Background: Cancer-secreted high mobility group 1 (HMGB1) induces apoptosis of macrophages and suppresses the host anti-cancer immune system.

Objective: We here examined the effect of HMGB1 on macrophages in the lymph nodes of colorectal cancer (CRC) patients.

Methods: Regional lymph nodes of 50 Dukes C CRCs were compared with 50 Dukes B CRCs.

HMGB1 attenuates anti-metastatic defence of the liver in colorectal cancer.

High mobility group box (HMGB) 1 induces apoptosis of monocyte-lineage cells. We examined the effect of HMGB1 on Kupffer cells (KCs). In 50 Dukes C and 12 liver-metastasised Dukes D colorectal cancers (CRCs), higher HMGB1 concentration in the primary tumours and metastatic foci, and fewer KCs were found in Dukes D cases than in Dukes C cases.

Antisense phosphorothioate oligodeoxynucleic acid for CD10 suppresses liver metastasis of colorectal cancer.

CD10 expression is associated with metastases of colorectal cancer (CRC). In the present study, we examined association of CD10 with liver metastasis of CRC cells to clarify the therapeutic significance of CD10. CD10-positive human colon cancer cell line, HT29 cells showed inhibition of growth, invasion and colony formation by treatment with CD10 antisense S-oligodeoxynucleotide (S-ODN).

Recurrence of keratocystic odontogenic tumor: clinicopathological features and immunohistochemical study of the Hedgehog signaling pathway.

Aims: Critical factors responsible for the recurrence of keratocystic odontogenic tumor (KCOT) were examined.

Methods: The clinicopathological features were retrospectively studied in 74 patients with 75 sporadic KCOTs. From the 75 KCOTs, 23 were examined for the expression of Sonic Hedgehog (SHH), Patched and Smoothened (SMO) by immunohistochemistry.

Protection of telomeres 1 protein levels are associated with telomere length in gastric cancer.

Protection of telomeres 1 (Pot1) is a telomere-associated protein, which binds to the single-stranded DNA extensions of telomeres and regulates telomere length. Pot1 production was examined and compared with telomere length in gastric cancer. Pot1 production and telomere lengths were assessed in 5 human gastric cancer cell lines by immunoblotting and Southern blotting, respectively.

Anti-tumor effects of liposome-encapsulated titanium dioxide in nude mice.

Anatase particles of titanium dioxide (TiO2) absorb ultraviolet (UV) light which is shorter than 415 nm. Photoexcited TiO2, a strong oxidizer, is expected to inhibit malignant cell growth. Liposomes accelerate endophagocytosis to the cytoplasm of encapsulated materials.