Tranexamic Acid Improves the Disrupted Formation of Collagen and Fibrillin-1 Fibers Produced by Fibroblasts Repetitively Irradiated with UVA.

The dermis is mainly constructed by type I collagen fibers, which provide mechanical strength to the skin by building a frame-like structure, and by elastic fibers, which provide elasticity to respond to movements of the skin. The depletion of collagen fibers and the disappearance of oxytalan fibers, which are a type of elastic fiber, are characteristic changes in photoaged skin. Prostaglandin E (PGE) is one of the chemical mediators involved in inflammation and is responsible for sunburn.

Carboxylated phytosterol derivative-introduced liposomes for skin environment-responsive transdermal drug delivery system.

Transdermal drug delivery systems are a key technology for skin-related diseases and for cosmetics development. The delivery of active ingredients to an appropriate site or target cells can greatly improve the efficacy of medical and cosmetic agents. For this study, liposome-based transdermal delivery systems were developed using pH-responsive phytosterol derivatives as liposome components.

Development of the novel plant-derived lanolin substitute and its cosmetic applications.

We have developed Bis-beheyl/isostearyl/phytosteryl dimer dilinoleyl dimer dilinoleate (oligomer ester) as a novel plant-derived lanolin or adsorption refined lanolin substitute with very pale color (GH = 1), low odor, and excellent stability. It is an oligomer ester type phytosterol ester in a paste form synthesized only from plant-derived materials. This oligomer ester has excellent lanolin-like properties such as high water holding capability (200%), excellent moisturizing effect in human use tests excellent gloss in makeup products (superior to lanolin and adsorption refined lanolin) coming from its high refractive index (approx.