Publications by authors named "Yukihiro Kumeta"
Article Synopsis
- Genetic factors, specifically single-nucleotide polymorphisms (SNPs), are important in understanding postoperative nausea and vomiting (PONV), but findings from previous studies often don't apply to different populations due to genetic variations.
- A study was conducted using a Japanese-specific DNA microarray to analyze the relationship between 659,636 SNPs and PONV in 24 female surgical patients, identifying 78 SNPs associated with the condition.
- Among these, the T > C variant of rs11232965 in the long non-coding RNA MIR4300HG showed a significant protective effect against PONV, suggesting it could be a new target for further research.
Aim: The aim of the present study was to investigate the effects of individualized nutritional treatment on the activities of daily living of acute stroke patients.
Methods: This was a randomized controlled study. The eligibility criteria were acute stroke, age >65 years and the presence of malnutrition risk.
Genetic variants, such as single-nucleotide polymorphisms (SNPs), of the μ-opioid receptor gene (OPRM1) might be associated with individual differences in opioid sensitivity, as well as with the incidence and severity of postoperative nausea and vomiting (PONV). The goal of the present study was to determine, in a cohort of Japanese surgical patients, genotypes and haplotypes of several SNPs in the OPRM1 gene, and their association with PONV during the early (first 24 h) postoperative period. We examined the incidence and severity of PONV, during the first 24 h after surgery, in 85 Japanese patients receiving intravenous patient-controlled analgesia fentanyl analgesia for postoperative pain control.
View Article and Find Full Text PDFA 60-year-old man with angina was scheduled for total gastrectomy, splenectomy, and cholecystectomy. Bare-metal stents were implanted into his left anterior descending coronary artery four weeks before the operation. Aspirin and clopidogrel were administered until one week before the operation and then injection of to 15,000 units of heparin per day was given.
View Article and Find Full Text PDFPurpose: Fentanyl was compared with nitrous oxide/sevoflurane as an adjuvant anesthesia to propofol during induction.
Methods: Two-hundred sixty-three patients of American Society of Anesthesiologists physical status 1 or 2 undergoing minor surgery were randomly divided into two groups. Group F patients (n = 125) received 2 microg x kg(-1) fentanyl and 1.
The direct application of preservative-free morphine sulfate (1.5%, 1 ml, 19.8 mumol) or fentanyl (0.
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