Publications by authors named "Yukie Nakashita"
Article Synopsis
- Hyperglycemia leads to an imbalance in how renal mitochondrial respiratory complexes are regulated, contributes to oxidative stress, and is linked to diabetic nephropathy.
- The study used mouse models to examine the impact of glomerular hyperfiltration on these mitochondrial complexes, finding that both diabetic and hyperfiltering kidneys showed signs of damage.
- Results indicated that the activities and protein levels of mitochondrial complexes were inconsistently regulated in the hyperfiltering model, suggesting that mitochondrial dysfunction may worsen nephropathy in the context of diabetes and hypertension.
Drug-induced liver injury (DILI) is a severe drug adverse response, which cannot always be reliably predicted in preclinical or clinical studies. Lack of observation of DILI during preclinical and clinical drug development has led to DILI being a leading cause of drug withdrawal from the market. As DILI is potentially fatal, pharmaceutical companies have been developing in vitro tools to screen for potential liver injury.
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