Publications by authors named "Yuki Tsutsumi"
ApcMin/+ mouse was a model mouse for human familial adenomatous polyposis, and irradiation at an early age increases tumors in the small and large intestine. To study the effects of antioxidant administration on tumor incidence after continuous whole-body exposure to gamma rays, ApcMin/+ mice were exposed to a medium-dose-rate, 200 mGy/d, from postnatal Day 0 to 21 of age or a high-dose-rate of 0.65 Gy/min (total dose 4.
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- - The study explored how chronic low-dose-rate radiation affects gene expression related to immune defense and epigenetic regulation in male mice's testis.
- - Results showed that exposure to radiation significantly reduced epigenetic regulation gene expression while increasing genes associated with innate and acquired immunity, indicating a strong impact on immune response.
- - Additionally, there was a rise in the expression of the SRY-box transcription factor 9, which is vital for testicular development, highlighting the biological consequences of this radiation exposure.
Background: We investigated the outcomes of postoperative radiation therapy for olfactory neuroblastoma (ONB) and our cross-departmental collaboration to enhance the effectiveness of cancer treatment.
Methods: We retrospectively evaluated 22 patients with ONB who underwent postoperative radiotherapy after tumor resection. En bloc resection was performed; pathology specimens were prepared in coronal sections; and irradiation fields were determined after discussion with radiation oncologists, head and neck surgeons, and pathologists.
To reduce the cost of inspecting old sewer pipes, we have been developing a low-cost sewer inspection system that uses drifting wireless cameras to record videos of the interior of a sewer pipe while drifting. The video's data are transmitted to access points placed in utility holes and further transmitted to a video server where each video frame is linked to its capturing position so that users can identify the damaged areas. However, in small-diameter sewer pipes, locating drifting nodes over the full extent of the pipeline using Wi-Fi-based localization is difficult due to the limited reach of radio waves.
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- A study analyzed the long-term outcomes of 693 patients with intermediate-risk prostate cancer treated with high-dose radiation, focusing on favorable vs. unfavorable subgroups.
- Results showed that patients with unfavorable disease had significantly shorter survival rates compared to those with favorable disease, particularly if they had multiple unfavorable factors.
- The conclusion suggests that patients with two or more unfavorable findings should receive a combination of treatment methods rather than just low-dose-rate brachytherapy alone for better outcomes.
Purpose: To assess the outcomes of high-dose-rate (HDR) brachytherapy and hypofractionated external beam radiation therapy (EBRT) combined with long-term androgen deprivation therapy (ADT) in very-high-risk (VHR) versus high-risk (HR) prostate cancer (PCa), as defined in the National Comprehensive Cancer Network (NCCN) criteria.
Methods: Data from 338 consecutive HR or VHR PCa patients who had undergone this tri-modal therapy between 2005 and 2018 were retrospectively analyzed. Biochemical recurrence (BCR)-free, progression-free, overall, and cancer-specific survival (BCRFS/PFS/OS/CSS) rates were analyzed using the Kaplan-Meier method and Wilcoxon test.
Calorie restriction is known to influence several physiological processes and to alleviate the late effects of radiation exposure such as neoplasm induction and life shortening. However, earlier related studies were limited to acute radiation exposure. Therefore, in this study we examined the influence of chronic low-dose-rate irradiation on lifespan.
View Article and Find Full Text PDFEfficacy of intensity-modulated radiation therapy for optic nerve sheath meningioma.
Graefes Arch Clin Exp Ophthalmol
October 2019
Purpose: The present study examined the efficacy and complications associated with intensity-modulated radiation therapy (IMRT) for optic nerve sheath meningioma (ONSM) in 15 cases and compared visual function before and after treatment.
Methods: Consecutively diagnosed patients with ONSM treated with IMRT were evaluated from 2012 to 2017. We categorized ONSM with three growth patterns (diffuse, fusiform, or globular).
Article Synopsis
- The abscopal effect is when localized radiation therapy not only shrinks the targeted tumor but also affects tumors in other areas of the body.
- A 76-year-old woman with lung cancer initially had surgery, but later developed lymph node metastases and received radiation treatment.
- After radiation, her lymph node metastases shrank, and surprisingly, tumors in her lungs completely disappeared without any chemotherapy, showcasing the abscopal effect in action.
Purpose: This multicenter study was conducted to evaluate the current variability of treatment planning of seed implantation in Japanese centers and the feasibility of two virtual trials.
Methods And Materials: Two types of contour data were sent to 12 radiation oncologists with a request letter that asked them to make treatment plans on the data in the same manner as in their own practice. Five of the 12 radiation oncologists were asked to participate in the two virtual trials in which the D90 (dose to the hottest 90% of prostate volume) was 1) required to be set at just 180 Gy and 2) increased as much as possible without violating other limitations.
Benzo[c]phenanthrene (BcP) is a highly toxic polycyclic aromatic hydrocarbon (PAHs) found throughout the environment. In fish, it is metabolized to 3-hydroxybenzo[c]phenanthrene (3-OHBcP). In the present study, we observed the effects of 1nM 3-OHBcP on the development and gene expression of Japanese medaka (Oryzias latipes) embryos.
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