Preparation of Tenuifolin from L. Root Using a Hydrolytic Continuous Flow System under High-Temperature, High-Pressure Conditions.

An improved process for preparing tenuifolin (presenegenin 3-β-d-glucopyranoside) from the root of L. was developed. A crude saponin mixture extracted from was subjected to hydrolysis, and the reactivity of compounds in the extract was controlled by utilizing the combination of a flow reactor and experimental design.