Impact of SARS-CoV-2 inactivated vaccine on symptoms following omicron variant breakthrough infection.

The SARS-CoV-2 Omicron variant and its sublineages continue to circulate widely. Clinical outcomes with this variant differ among individuals, primarily influenced by host immunity. Previous studies have explored the relationship between immune responses and severe diseases in infected or convalescent patients.

Real-World Effectiveness of Ensitrelvir in Reducing Severe Outcomes in Outpatients at High Risk for COVID-19.

Introduction: This study aimed to evaluate the effectiveness of ensitrelvir, an oral antiviral, in reducing hospitalization risk in outpatients at high-risk for severe COVID-19 during the Omicron era.

Methods: This was a retrospective study using a large Japanese health insurance claims database. It included high-risk outpatients for severe symptoms who received their first COVID-19 diagnosis between November 2022 and July 2023.

Compressed glassy carbon maintaining graphite-like structure with linkage formation between graphene layers.

Amorphous diamond, formed by high-pressure compression of glassy carbon, is of interests for new carbon materials with unique properties such as high compressive strength. Previous studies attributed the ultrahigh strength of the compressed glassy carbon to structural transformation from graphite-like sp-bonded structure to diamond-like sp-bonded structure. However, there is no direct experimental determination of the bond structure of the compressed glassy carbon, because of experimental challenges.