Publications by authors named "Yuki Okuhiro"
Article Synopsis
- - Gemcitabine and Docetaxel (GEM/DTX) are common chemotherapy drugs used for soft tissue sarcomas but their effectiveness against malignant rhabdoid tumors (MRTs) is not well-studied.
- - In a small study, GEM/DTX was used as salvage therapy for relapsed MRTs, showing partial responses in 3 out of 4 patients, including two with malignant rhabdoid tumors of the kidney.
- - While GEM/DTX shows potential for treating resistant MRTs, there are specific side effects that require careful monitoring, such as localized edema and pleural effusion.
Ponatinib is a third-generation tyrosine kinase inhibitor (TKI) reported to show a higher efficacy for adult Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL) than other TKIs. However, few studies describe ponatinib for pediatric Ph+ALL; therefore, the efficacy, safety, and optimal dosage have not been determined. Here, we report a 3-year-old girl with Ph+ALL treated by a ponatinib-containing regimen with therapeutic drug monitoring in the plasma and cerebrospinal fluid (CSF).
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- Atypical teratoid/rhabdoid tumor (AT/RT) is a rare and serious brain tumor that mostly affects young kids and is hard to treat.
- Researchers created a special cell line from a patient's AT/RT tumor to test different cancer drugs and found that bortezomib, along with some other drugs, worked really well against these cells.
- They discovered that using bortezomib together with another drug called panobinostat could be a promising way to treat AT/RT more effectively.