Publications by authors named "Yuki Okado"
Adacolumn is a therapeutic mode for ulcerative colitis that achieves therapeutic efficacy through the adhesion of leukocytes to cellulose acetate beads. We used scanning electron microscopy and observed leukocyte adsorption on Adacolumn beads after granulocytapheresis/granulocyte and monocyte adsorption apheresis. We then compared results between two patients with a low and high C-reactive protein (CRP) levels to determine whether adhesion is affected by a difference in leukocyte activity depending on the level of inflammation.
View Article and Find Full Text PDFBackground: Capsule endoscopy (CE) has allowed the characterization of small bowel lesions. However, small bowel lesions in ulcerative colitis (UC) have not been elucidated and no studies have compared between UC and Crohn's disease (CD).
Aim: The objective of this study was to investigate the small bowel lesions in UC, and to characterize UC lesions by comparison with CD.
Article Synopsis
- This study analyzed the incidence of intestinal complications like stenosis and fistulas in patients with Crohn's disease (CD) at a Japanese hospital, finding that about 50% develop these issues within 5 years.
- The research involved 520 patients and looked at the cumulative rates of initial surgeries, revealing that about 50% of patients required surgery after 10 years.
- Identified risk factors for undergoing initial surgery included being a current smoker and having moderate to severe stenosis in various parts of the intestines, particularly in those with upper gastrointestinal disease at diagnosis.
Background/aims: In Japan, aphthous-type Crohn's disease (type A CD) is thought to represent an early phase of Crohn's disease (CD), and diagnosis of type A CD is possible in the diagnostic criteria for CD in Japan. However, the details of type A CD are not well understood.
Methods: Subjects comprised 649 CD patients diagnosed between 1985 and 2011.
Cancer risk in Japanese Crohn's disease patients: investigation of the standardized incidence ratio.
J Gastroenterol Hepatol
August 2013
Background And Aim: There have been very few reported investigations on the standardized incidence ratio (SIR) of intestinal cancer and all cancers other than intestinal cancer with Crohn's disease (CD) by organ in Japan. This study examined the risk of developing cancer (i.e.
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