Publications by authors named "Yuki Marugame"
Delphinidin, a plant anthocyanidin, suppresses disuse muscle atrophy in mice. However, its effect on muscle fiber type shift is unclear. To examine whether delphinidin affects skeletal muscle fiber type, differentiated C2C12 cells were treated with delphinidin.
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- * Mice were given EGCG orally for one week, leading to changes in the expression of 35 circRNAs in their livers, as identified through circRNA microarray testing.
- * Specifically, mmu_circRNA_011775, a circRNA upregulated by EGCG, was linked to gene expression changes associated with liver fibrosis and cardiovascular health, as shown by next-generation sequencing and gene ontology analysis.
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- Epidemiological studies suggest a link between inflammatory bowel disease (IBD) and dementia, particularly focusing on cognitive impacts in adolescents with IBD.
- This research used a mild chronic colitis model in adolescent mice to assess the effects on cognitive function and hippocampal neurogenesis as they grew into adulthood.
- Results showed that mild chronic colitis was linked to cognitive decline and reduced neurogenesis, alongside neuroinflammation in the hippocampus, highlighting a potential risk of dementia associated with IBD.
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- - Pulmonary fibrosis (PF) has a high mortality rate, making the search for effective prevention and treatment strategies crucial; one promising approach involves the use of (-)-Epigallocatechin-3-gallate (EGCG), a compound found in green tea that shows antifibrotic properties.
- - A study examined how EGCG influences microRNAs (miRNAs) found in extracellular vesicles from human umbilical vein endothelial cells (HUVECs) and identified 31 miRNAs that were affected by EGCG, with 27 being increased and 4 decreased.
- - Notably, miR-6757-3p was found to potentially target the TGF-β receptor 1 (TGF
Many patients with allergies have anxiety about taking anti-allergic medicines due to their side effects and increased medical expenses. Thus, developing functional foods/agricultural products for allergy prevention is strongly desired. In this study, we revealed that a Citrus flavanone, hesperetin, amplified IgE/antigen-mediated degranulation-inhibitory potency of anti-allergic catechin, (-)-epigallocatechin-3-O-(3-O-methyl) gallate (EGCG3''Me), in the rat basophilic/mast cell line RBL-2H3.
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- The study investigates the health benefits of polyphenols, particularly flavonoids, and their impact on circulating microRNAs (miRNAs) as potential biomarkers for diseases.
- Researchers conducted miRNA microarray analysis on mice given different flavonoids (daidzein, quercetin, and delphinidin), finding significant changes in certain plasma miRNA levels compared to a control group.
- Results indicate that flavonoids can modify miRNA expression in plasma, pointing to specific miRNAs as potential indicators for evaluating the health effects of flavonoids.
Sesame lignans upregulate glutathione S-transferase expression and downregulate microRNA-669c-3p.
Biosci Microbiota Food Health
January 2022
Oxidative stress is associated with aging and pathologies such as cardiovascular diseases, Alzheimer's disease, and cancer. Glutathione S-transferase (GST), a family of detoxification enzymes, plays a crucial role in countering oxidative stress. Therefore, there is a need for the development of physiologically functional foods and agricultural products, which enhance GST activity.
View Article and Find Full Text PDF(-)-Epigallocatechin-3--(3--methyl) gallate (, EGCG3″Me), an antiallergic -methylated catechin, is present in high quantities in the green tea cultivar "Benifuuki" ( L.). Previous studies have shown that EGCG3″Me inhibited basophil degranulation mediated through the cell-surface 67-kDa laminin receptor (67LR), but the mechanisms are not fully elucidated.
View Article and Find Full Text PDFAnimal and clinical studies have revealed that (-)-epigallocatechin-3-O-gallate (EGCG), one of the major bioactive polyphenols in green tea, showed several pharmacological effects including anti-obesity effect and anti-inflammatory effect. We previously reported that the second messenger cyclic guanosine monophosphate (cGMP) mediates its anti-inflammatory and anti-cancer properties. Here we demonstrated that glucosyl-hesperidin, enhances the cGMP-inducing effects of green tea extract in vivo.
View Article and Find Full Text PDFFolic acid and folate receptors (FOLRs) play an important role in the downregulation of homocysteine (Hcy), a risk factor of Alzheimer's disease, thrombosis, neuropsychiatric illness and fractures. While several studies have reported that FOLR1 and FOLR2 import folic acid into cells, the role of FOLR3 remains unknown. In this study, we evaluated the impact of FOLR3 on the metabolism of Hcy alongside its protective effect against homocysteine-induced neurotoxicity.
View Article and Find Full Text PDF(-)-epigallocatechin-3-O-gallate (EGCG) is a bioactive polyphenol in green tea. Previous studies have demonstrated the beneficial effects of EGCG on muscle mass and muscle atrophy. In the current study, we investigated the mechanisms underlying effect of EGCG on muscle atrophy.
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