Publications by authors named "Yuki Kuroyama"

Background: In the treatment of patients with nontuberculous mycobacterial pulmonary disease (NTM-PD), pulmonary rehabilitation (PR) has been recommended as a non-pharmacological therapy. However, no study has validated the combination of chemotherapy and PR in this context. This study investigated the effect of chemotherapy and supervised PR on health-related quality of life (HRQoL) and physical function in NTM-PD patients.

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Objective: Preoperative performance status is an important factor in thoracic surgery, but little is known about the effect of preoperative physical activity (PA) on the postoperative course. This study investigated the associations between preoperative PA and postoperative complications and clinical outcomes of lung cancer surgery.

Methods: This prospective observational study included patients who underwent surgery for lung cancer at a single institution.

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Article Synopsis
  • The study investigates how chronic sputum (CS) symptoms impact health-related quality of life (HRQOL) in patients with nontuberculous mycobacterial pulmonary disease (NTM-PD) for the first time.
  • Among 99 patients, 71 were identified with CS, showing they had worse pulmonary function and more severe disease as indicated by radiological evaluations.
  • The analysis revealed that CS significantly correlated with lower mental health scores in HRQOL assessments, highlighting its detrimental effect on patients' overall well-being.
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Purpose: To investigate the exercise capacity and health-related quality of life (HRQOL) of surgical patients with nontuberculous mycobacterial pulmonary disease (NTM-PD) preoperatively versus 6 months postoperatively.

Methods: This prospective observational study included patients with NTM-PD and was conducted at a single center. The intervention was surgical resection plus perioperative and post-discharge physical therapy.

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Article Synopsis
  • The study aimed to assess the prevalence and severity of bodily pain in patients with nontuberculous mycobacterial pulmonary disease (NTM-PD), focusing on a group of 114 participants, mostly women with an average age of 65.
  • Pain affected 70.2% of the participants, with over one-third experiencing moderate to very severe pain, which correlated with higher levels of dyspnea, depression, and poor sleep quality.
  • Key factors influencing pain included exercise tolerance, depressive symptoms, and sleep quality, indicating that pain significantly impacts the daily lives of NTM-PD patients.
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  • - The study aimed to evaluate depressive symptoms in patients with nontuberculous mycobacterial pulmonary disease (NTM-PD) using two common screening tools: CES-D and HADS-D.
  • - Findings indicated a prevalence of depressive symptoms at 37.9% with CES-D and 26.3% with HADS-D, highlighting significant differences in results between the two tools.
  • - Cough was identified as a key predictor of depressive symptoms, reflecting the need for awareness and interventions to address mental health in NTM-PD patients.
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  • * Researchers analyzed medical records of 81 patients, finding significant correlations between the SGRQ and LCQ scores, indicating both questionnaires can reflect aspects of HRQOL in NTM-LD.
  • * The LCQ may be particularly valuable for assessing HRQOL as it focuses on cough-related symptoms, and key factors like lung function and radiological scores impact scores from both HRQOL assessments.
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The incidence of nontuberculous mycobacterial lung disease (NTMLD) is increasing worldwide, the number of lung surgeries is increasing accordingly. The disease is progressive and is characterized by exertional intolerance, respiratory dysfunctions, and impaired health-related quality of life (HRQOL). Treatment comprises multidrug antibiotic treatment combined with lung resection.

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