Cardiovascular Toxicity Profile of Macrolides Investigated Using VigiBase Data: A Pharmacovigilance Study.

Macrolides are associated with cardiovascular toxicity risk. However, data on their cardiovascular toxicity profiles beyond QT prolongation are limited, and differences in the profiles among various macrolide antibiotics remain unclear. We investigated the cardiovascular toxicity profiles of different macrolides using VigiBase, a global database of individual case-safety reports.

Noise reduction performance of a deep learning-based reconstruction in brain computed tomography images acquired with organ-based tube current modulation.

We aimed to evaluate the image quality of brain computed tomography (CT) images reconstructed using deep learning-based reconstruction (DLR) in organ-based tube current modulation (OB-TCM) acquisition. An anthropomorphic head phantom and a cylindrical low-contrast phantom were scanned at the standard dose level for adult brain CT in axial volume acquisition without OB-TCM. Moreover, image acquisition with OB-TCM was performed.

Image quality comparison of a nonlinear image-based noise reduction technique with a hybrid-type iterative reconstruction for pediatric computed tomography.

Purpose: To compare computed tomography (CT) image properties between a vendor-independent image-based noise reduction technique, Image-space Noise Reduction (iNoir) and a hybrid-type iterative reconstruction technique, Adaptive Statistical Iterative Reconstruction (ASIR).

Methods: A cylindrical water phantom, corresponding to pediatric body size, containing soft-tissue-equivalent rod and 12-mg iodine/ml rod was scanned at size-specific dose estimates of 8.4 and 16.

Radiation dose reduction to the eye lens in head CT using tungsten functional paper and organ-based tube current modulation.

Purpose: We investigated whether a tungsten functional paper (TFP) shield and/or organ-based tube current modulation (TCM) can reduce the dose to the eye lens.

Materials And Methods: All scans were performed using our routine head examination protocol (spiral acquisition, 120 kVp, noise Index 3.5) with an anthropomorphic head phantom.

Complexes of Eu(iii)(hfa) with a planar chiral P(iii) ligand (Phanephos): solvent-sensitive sign inversion of circularly polarised luminescence.

Complexes of Eu(iii)(hfa) with a C-symmetric planar P(iii) ligand exhibited intense circularly polarised luminescence (CPL) due to D → F and D → F transitions, with the signs and shapes of CPL signals depending on the choice of solvent (acetone or chloroform).

Putative host cell receptor for fowl adenovirus detected in gizzard.

This work was done to identify a fowl adenovirus (FAV) binding protein in the gizzard, a known target organ for certain strains of FAV serotype 1. By using a virus overlay protein binding assay (VOPBA), a putative FAV binding protein of approximately 200 kDa expressed in the gizzard was detected.