Publications by authors named "Yuki Kaya"
Article Synopsis
- Endotoxins (LPS) are problematic in bacterial protein production, but researchers developed a method using a special bacterium that lacks LPS.
- They successfully created endotoxin-free proteins, including functional green fluorescent protein and the cytokine TNF-α, and significantly reduced contamination levels.
- This new system also enabled the production of a specific antibody targeting the coronavirus spike protein and a rheumatoid arthritis drug, showcasing its potential for future applications in biotechnology.
Microbiol Spectr
October 2022
Article Synopsis
- * This study examined how colistin-resistant A. baumannii strains arise, showing that while colistin alone leads to LPS-deficient strains, combining it with other antibiotics results in strains with modified LPS.
- * The findings indicate that LPS-deficient strains are less fit and more susceptible to other treatments, suggesting that LPS-modified strains are more prevalent in clinical settings, highlighting the urgent need to address colistin resistance in healthcare.
