Publications by authors named "Yuki Hatakeyama"
A case of cerebral amyloid angiopathy with ipsilateral tau and contralateral amyloid PET uptake related to cadaveric dura mater implanted in childhood.
Eur J Nucl Med Mol Imaging
December 2024
Article Synopsis
- Researchers developed a co-culture model using induced pluripotent stem cells (iPSCs) to better simulate brain interactions by combining neurons and astrocytes, overcoming the limitations of single-cell type monoculture models.
- This new model demonstrated increased neuronal activity and structural changes, such as astrocyte branching and synapse formation, which are vital for reflecting a more realistic brain environment.
- The co-culture model of iPSCs from a familial Alzheimer's disease patient exhibited disease-specific phenotypes, like astrogliosis, that were not present in monoculture models, highlighting its potential for improving disease modeling.
Introduction: 17β-Estradiol (E2) is a sex hormone that has been previously demonstrated to have neurotherapeutic effects on animal models of Alzheimer's disease (AD). However, clinical trials on E2 replacement therapy for preventing AD onset yielded inconsistent results. Therefore, it is imperative to clarify the therapeutic effects of E2 on human cells.
View Article and Find Full Text PDFHuman neural cell models derived from induced pluripotent stem cells (iPSCs) have been widely accepted to model various neurodegenerative diseases such as Alzheimer's disease (AD) . Although the most common sources of iPSCs are fibroblasts and peripheral blood mononuclear cells, the collection of these cells is invasive. To reduce the donor's burden, we propose the use of urine-derived cells (UDCs), which can be obtained non-invasively from a urine sample.
View Article and Find Full Text PDFBackground: Listeria monocytogenes is a causative agent of food poisoning and is also known to cause invasive diseases, such as bacteremia, meningitis, and encephalitis, in neonates, elderly and immunocompromised patients. However, the clinical course of a multi-organ disseminated disease secondary to bacteremia has been rarely reported.
Case Presentation: A 76-year-old woman undergoing immunosuppressive therapy for rheumatoid arthritis presented to our outpatient clinic with a chief complaint of weight loss.