Publications by authors named "Yuki Ariyasu"
Article Synopsis
- A study explored how obesity affects kidney outcomes specifically in patients with immunoglobulin A nephropathy (IgAN), considering factors such as sex and kidney function.
- Researchers analyzed data from patients in Japan, categorizing them into normal and obese groups based on body mass index (BMI), and focused on renal function decline and the need for replacement therapy.
- Findings indicated that while obesity didn't show a direct impact on kidney prognosis, it was linked to having more risk factors for IgAN progression, particularly affecting women in terms of proteinuria and contributing to kidney damage like tubular atrophy.
Metabolic syndrome is associated with the development of chronic kidney disease (CKD). We previously demonstrated that aged kidneys are prone to developing tertiary lymphoid tissues (TLTs) and sustain inflammation after injury, leading to CKD progression; however, the relationship between renal TLT and metabolic syndrome is unknown. In this study, we demonstrated that a high-fat diet (HFD) promoted renal TLT formation and inflammation via sterol O-acyltransferase (SOAT) 1-dependent mechanism.
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