Folding of single-stranded circular DNA into rigid rectangular DNA accelerates its cellular uptake.

Despite the importance of the interaction between DNA and cells for its biological activity, little is known about exactly how DNA interacts with cells. To elucidate the relationship between the structural properties of DNA and its cellular uptake, a single-stranded circular DNA of 1801 bases was designed and folded into a series of rectangular DNA (RecDNA) nanostructures with different rigidities using DNA origami technology. Interactions between these structures and cells were evaluated using mouse macrophage-like RAW264.

[A case report of recurrence of liver metastases from colorectal cancer, which seemed to have vanished for a time by intra-aortic chemotherapy].

A 66-year-old man underwent lower anterior resection for rectum cancer with multiple liver metastases. The diagnosis was Stage IV well-differentiated tubular adeno carcinoma. n1H3M(-).

[Indication and meaning of hepatic resection for metastatic liver tumors from gastric cancer].

To clarify the efficacy and indication of hepatectomy in gastric cancer metastasis to the liver, we studied 26 liver metastases patients undergoing hepatectomy. The cumulative 5-year survival rations were 25.3%.