A newly devised flow cytometric antibody binding assay helps evaluation of dithiothreitol treatment for the inactivation of CD38 on red blood cells.

Background And Objectives: Anti-CD38 monoclonal antibodies, including daratumumab and isatuximab, often interfere with pretransfusion testing. Dithiothreitol (DTT) treatment of red blood cells (RBCs) negates this interference. However, the optimum DTT concentration and treatment time have not been well defined.

Tamibarotene maintenance improved relapse-free survival of acute promyelocytic leukemia: a final result of prospective, randomized, JALSG-APL204 study.

Between April 2004 and December 2010, we conducted a prospective randomized controlled study comparing tamibarotene with all-trans retinoic acid (ATRA) in the maintenance therapy of newly diagnosed acute promyelocytic leukemia (APL), and here report the final results of this study with a median follow-up of 7.3 years. Of 344 eligible patients who had received ATRA and chemotherapy, 319 (93%) achieved complete remission (CR).

Interactions between bradykinin and plasmin in the endothelial Ca response.

Plasmin is a fibrinolytic factor and a serine protease that activates protease-activated receptors (PARs) to produce endothelium-derived relaxing factors such as nitric oxide and prostacyclin. Nitric oxide and prostacyclin production is regulated, at least in part, by the intracellular Ca concentration in various blood vessel types. Bradykinin and plasmin stimulate vascular endothelial cells and work simultaneously in pathophysiological conditions such as thrombosis and inflammation.

[The Effectiveness of Two Anesthesia Machines in the Water Generation of the Anesthesia Circuit during the Prolonged Low Flow Desflurane Anesthesia].

Background: Water is generated by a reaction of carbon dioxide and a carbon dioxide absorbent We evaluated the effectiveness of the anesthesia machines about the water generation which occurs to an anes- thetic circuit during the prolonged low flow anesthesia.

Methods: Fifteen patients were divided into three groups; group HHS (n=5) in which a hot heater system was equipped inside anesthesia machine, group WCD (n=5) in which a water catchment device was connected with anesthesia machine, and control group N(n=5)in which normal anesthesia machine was used without special device, and studies were performed with FGF 11 - min- low flow desflurane anesthesia for more than 6 hours. The water situation in an anesthe- sia circuit was observed during the operation and was compared after the operation between these groups.

The Influence of Differences in Solvents and Concentration on the Efficacy of Propofol at Induction of Anesthesia.

Background. Propofol is a popular intravenous anesthetic and varieties of formulations were produced from different laboratories. The present study compared efficacy of propofol of different laboratories and different concentrations (1 and 2%) during induction of anesthesia.

Radial artery cannulation decreases the distal arterial blood flow measured by power Doppler ultrasound.

Radial arterial cannulation is a popular technique for continuous hemodynamic monitoring in an area of anesthesia and intensive care. Although the risk for invasive monitoring is considerable, there is scarce information about the change in blood flow of cannulated vessel after the catheterization. In the current investigation, we evaluated the change in the cannulated arterial blood flow.

Continuous administration of landiolol reduced QT dispersion in postoperative patients.

Study Objective: To determine the changes in QT dispersion (QTD) in the standard electrocardiogram (ECG) of postoperative patients and the effect of landiolol on QTD.

Design: Randomized, prospective, double-blinded study.

Patients: 40 postsurgical patients.

Dexmedetomidine-induced atrioventricular block followed by cardiac arrest during atrial pacing: a case report and review of the literature.

Sinus bradycardia is a well-known consequence of stimulation of presynaptic α2 adrenergic receptors due the adminstration of dexmedetomidine. One of the most serious adverse effects of dexmedetomidine is cardiac arrest. Some cases demonstrating such an arrest due to the indiscriminate use of this drug were recently reported.

The effect of aging on dopamine release and metabolism during sevoflurane anesthesia in rat striatum: an in vivo microdialysis study.

We have previously reported that halothane anesthesia increases extracellular concentrations of dopamine (DA) metabolites in rat striatum using in vivo microdialysis techniques. Aging induces many changes in the brain, including neurotransmission. However, the relationship between aging and changes in neurotransmitter release during inhalational anesthesia has not been fully investigated.

[Sudden increases and decreases in bispectral index values more than 30 within 1 minute during general anesthesia].

We described, in a 40-year-old man, sudden and unexpected increases in bispectral index values during the general anesthesia with total intravenous anesthesia using propofol in a dental surgery. The patient was administered continuous infusion of propofol and remifentanil, and intermittent supplementation of fentanyl. Immediately after the beginning of surgery, the bispectral index value increased abruptly to 90; whereas, heart rate and non-invasive blood pressure were unchanged and no physiological finding was observed.

Dexmedetomidine and hydroxyzine synergistically potentiate the hypnotic activity of propofol in mice.

Purpose: Investigation into the characteristics of anesthetic interactions may provide clues to anesthesia mechanisms. Dexmedetomidine, an α(2)-adrenergic receptor agonist, has become a popular sedative in intensive care, and hydroxyzine, a histamine receptor antagonist, is well known as a tranquilizing premedication for anesthesia. However, no experimental or pharmacological evaluation has been reported concerning their combination with propofol.

[Pycnodysostosis: a case report].

A 53-year-old man suffered maxillar osteomyelitis and removal of sequester was scheduled under general anesthesia. Pycnodysostosis had been diagnosed in childhood and body height and weight were 148 cm and 40 kg, respectively. He presented facial dysmorphia, hypomobile mandible and narrow oral cavity.

[Successful extubation in a patient with alacepril-induced tongue angioedema].

We describe a case of marked swelling of the tongue in a patient after a long prone position neurosurgery, who was treated for hypertension with alacepril. The tongue was not congestive and history of taking an angiotensin-converting enzyme inhibitor suggested an alacepril-induced angioedema. The day after surgery, the patient's tongue was still swollen; however, fibrescopic observation of the larynx and pharynx through the nasal cavity revealed that the edema was limited to anterior tongue, and the oral cavity and oropharynx were not involved.

[Apnea and severe respiratory depression induced by dexmedetomidine after general anesthesia in intensive care unit].

Dexmedetomidine (DEX) is widely used in intensive care unit for perioperative sedation. The one advantage of DEX administration for sedation is the lack of significant respiratory depression. However, DEX shows significant interaction with anesthetics and narcotics, and we present a case in which post-anesthetic administration of DEX induced apnea and severe respiratory depression after extubation.

[Serotonin syndrome caused by an overdose of dextromethorphan, Medicon].

We report the first case of serotonin syndrome caused by overdose of dextromethorphan in Japan. A 34-year-old woman with schizophrenia received a dextromethorphan (Medicon) for a catarrhal symptom from two individual departments of the university hospital by chance. The daily amount of dextromethorphan was up to 180 mg for several days in addition to other regular antipsychotic drugs including risperidone, amitriptyline and levomepromazine.

Nafamostat prevents hypothermia and improves survival time after administration of lipopolysaccharide in a mouse surgical model.

Lipopolysaccharide (LPS) is an endotoxin known to induce disseminated intravascular coagulation and multiple organ failure followed by septic shock in animals. Nafamostat is a synthetic protease inhibitor with anticoagulant effects. This study investigated the effect of systemic administration of nafamostat on thermogenic homeostasis and survival time in a mouse surgical model.

[Difficult airway management due to obesity and lingual tonsillar hyperplasia].

We experienced anesthesia for a female patient of BMI 39.2 with unanticipated lingual tonsillar hyperplasia. At the induction of anesthesia, both mask ventilation and tracheal intubation were difficult due to the lingual tonsillar hyperplasia.

[Two cases of anesthesia mumps in the upper parotid gland after general anesthesia in the lateral position].

We describe two cases of acute transient swelling of the upper side of parotid glands of the patients after general anesthesia in the lateral position. The serum amylase levels in the patients were not increased and the enlargement of the parotid gland was diagnosed as anesthesia mumps. Previous reports suggested that mechanical compression might produce the swelling of the secreting organ, but our patients showed temporal parotid enlargement in the upper free side.

[Severe arrhythmia after gastrectomy in patients with history of coronary bypass graft surgery using right gastroepiploic artery].

The authors reported two cases of severe arrhythmia after gastrectomy in the patients with history of coronary bypass grafting (CABG) using the right gastroepiploic artery. The first patient was a 64-year-old man who had undergone CABG involving bypassing between the right coronary artery and the right gastroepiploic artery 5 months before. Partial gastrectomy was performed without significant complications.