Publications by authors named "Yuka Yamagata"
High-density lipoprotein (HDL) cholesterol is a well-known biomarker, which has been associated with reduction in the risk of cardiovascular diseases (CVD). However, some HDL anti-atherosclerotic functions may be impaired without altered HDL-cholesterol (HDL-C) level via its dysfunctional proteins or other physiological reactions in vivo. We previously showed that activated mast cell-derived chymase could modestly cleave apolipoprotein A-I (apoA-I) in HDL and further easily cleave lipid-free apoA-I.
View Article and Find Full Text PDFA case report involving suppressed nuclear receptor transcription factors 4a1 and Stevens-Johnson syndrome induced by a single dose of pembrolizumab and successfully treated with early steroid administration, resulting in complete remission of stage III lung cancer.
J Pharm Health Care Sci
December 2022
Article Synopsis
- A 68-year-old male with stage IIIb squamous cell lung cancer developed Stevens-Johnson syndrome (SJS) after receiving a single dose of the immunotherapy drug pembrolizumab, which was treated successfully with steroids, leading to complete cancer remission for over a year.
- The onset of SJS was correlated with significant changes in immune markers, including increased levels of IFN-γ and IL-17, and decreased IL-10, which were linked to lower expression of the Nr4a1 mRNA transcription factor.
- This case suggests that suppressing Nr4a1 may enhance the activity of cytotoxic T cells while reducing regulatory T cell function, potentially improving the effectiveness
Triglyceride hydrolysis by lipoprotein lipase (LPL), regulated by apolipoproteins C-II (apoC-II) and C-III (apoC-III), is essential for maintaining normal lipid homeostasis. During triglyceride lipolysis, the apoCs are known to be transferred from very low-density lipoprotein (VLDL) to high-density lipoprotein (HDL), but the detailed mechanisms of this transfer remain unclear. In this study, we investigated the extent of the apoC transfers and their distribution in HDL subfractions, HDL2 and HDL3.
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