Publications by Yuka Tarui

Publications by authors named "Yuka Tarui"

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Terpendole E and its derivative inhibit STLC- and GSK-1-resistant Eg5.

Yuka Tarui Takumi Chinen Yoko Nagumo Takayuki Motoyama Toshiaki Hayashi

Chembiochem

May 2014

Terpendole E is first natural product found to inhibit mitotic kinesin Eg5, but its inhibitory mechanism remains to be revealed. Here, we report the effects of terpendole E and 11ketopaspaline (a new natural terpendole E analogue) on the Eg5-microtubule interaction and in several Eg5 mutants. 11-Ketopaspaline is a shunt product from terpendole E, and it shows potent inhibitory activity against the microtubule-stimulated ATPase activity of Eg5.

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