Publications by authors named "Yuka Otagiri"
Article Synopsis
- Metastasis is a leading cause of cancer deaths and is heavily influenced by the protease MT1-MMP, which plays a key role in local invasion and spreading of cancer cells.
- The transport of MT1-MMP from the endoplasmic reticulum to invadopodia is complex and involves the diversion of a protein called Bet1, which typically helps in transporting other proteins to the Golgi apparatus.
- The study finds that MT1-MMP's interaction with Bet1 and other proteins facilitates its movement to the cell surface, enhancing its role in cancer cell invasiveness.
