Publications by authors named "Yuka Nagasaka"
Background: Resident memory T (T) cells and immunosuppressive Foxp3-expressing regulatory T (regT) cells are present in healthy, non-inflamed and inflamed human skin. Both types of cells are found in both the epidermis and dermis with the dermis being much thicker than the epidermis. However, it is unclear if T and regT cells differ between reticular dermal layers in terms of number, function or characteristics.
View Article and Find Full Text PDFCha o 3, a cypress pollen allergen, does not activate basophils in Japanese cypress pollinosis.
J Allergy Clin Immunol Glob
February 2024
Article Synopsis
- In Japan, JCy pollinosis (a seasonal allergy) is primarily caused by two major allergens from Japanese cypress pollen: Cha o 1 and Cha o 2, with a new allergen, Cha o 3, recently identified.
- A study with 27 patients examined the allergenic effects of Cha o 3 compared to Cha o 1 and Cha o 2 using basophil activation tests and IgE suppression tests.
- The findings showed that Cha o 3 activated basophils much less than Cha o 1 and Cha o 2, suggesting it is not a significant allergen in JCy pollinosis.
Article Synopsis
- - Bmal1 is a transcription factor important for the circadian clock and has an unclear role in mast cell function, which is crucial in allergic reactions and follows a daily rhythm.
- - The study found that mast cells lacking Bmal1 showed increased IgE-dependent degranulation and higher oxidative stress markers compared to normal mast cells, suggesting a link between Bmal1 and mast cell activity.
- - Overall, the research indicates that Bmal1 regulates anti-oxidative gene expression in mast cells, and its deficiency leads to heightened allergic responses due to increased oxidative stress.
Article Synopsis
- Human skin has regulatory T cells (Tregs) in both the epidermis and dermis, but previous research mostly focused on the thicker dermal layer, which may skew our understanding of Tregs present in the skin.
- This study specifically examined Tregs found in the epidermis and other epithelial tissues by analyzing cells after they were cultured without additional stimulation.
- The findings revealed that a specific subset of Tregs (CD4CD103Foxp3) can suppress other T cells and are present in normal, noninflamed skin, indicating their role in immune regulation independent of factors like hair density and Langerhans cells.*
Article Synopsis
- Tissue-resident memory T cells are found in both the epidermis and dermis of human skin and require specific methods for isolation and analysis.
- Various isolation techniques, such as enzymatic digestion and spontaneous migration, have their own limitations, including reduced T-cell yield and antigen modification.
- The study reveals that while spontaneous migration recovers T cells effectively, it results in a loss of about 20% of T cells, highlighting the trade-offs between different methods for isolating skin T cells.
Tissue Expander-associated T Cells: Relevance to Breast Implant-associated Anaplastic Large-cell Lymphoma.
Plast Reconstr Surg Glob Open
March 2022
Article Synopsis
- The study explores the relationship between textured breast implants and the development of breast implant-associated anaplastic large-cell lymphoma (BIA-ALCL), particularly how different types of T cells are affected.
- Researchers analyzed tissue samples from patients with textured and smooth tissue expanders to understand T cell behavior in these environments.
- The findings reveal that textured implants lead to differences in T cell infiltration and differentiation, with textured implants not promoting the generation of specific CD4 resident memory T cells compared to smooth implants.