Publications by authors named "Yuk Hei Cheung"
Rieske-type non-heme iron oxygenases (ROs) are an important family of non-heme iron enzymes. They catalyze a diverse range of transformations in secondary metabolite biosynthesis and xenobiotic bioremediation. ROs typically shuttle electrons from NAD(P)H to the oxygenase component via reductase component(s).
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- - NHM-Fe enzymes are diverse in their catalytic abilities, featuring simple iron centers ligated by amino acids like histidine and aspartic acid.
- - A commonly found reactive iron intermediate, the S=2 oxyferryl (Fe(IV)-oxo), has been identified in certain NHM-Fe enzymes, but no common intermediate was known for 3-His/4-His-Fe enzymes until recently.
- - The review highlights the discovery of the first S=1 Fe(IV) intermediate in the enzyme OvoA, discussing its significance, differences from the S=2 species, and potential implications for other similar enzymes.