Publications by authors named "Yujun Ning"
Article Synopsis
- Targeted protein degradation (TPD) is being recognized as a promising strategy for treating diseases and advancing research, but traditional targeting chimeras struggle with effective self-diffusion and active searching in biological settings.
- MotorTACs, a new type of targeting chimera powered by nanomotors, show significant improvements in degrading extracellular PDGF, a protein linked to cancer spread, completing degradation in just 4 hours through enhanced internalization.
- The MotorTACs operate through established cellular pathways (lysosome and ubiquitin-proteasome), offering a potential solution for tackling hard-to-target proteins in disease treatment.
Accurate and reliable detection of SARS-CoV-2 is critical for the effective prevention and rapid containment of COVID-19. Current approaches suffer from complex procedures or a single signal readout, resulting in an increased risk of false negatives and low sensitivity. Here, we developed a fluorescence (FL) and electrochemiluminescence (ECL) dual-mode imaging platform based on a self-powered DNAzyme walker to achieve accurate surveillance of SARS-CoV-2 spike protein at the single-molecule level.
View Article and Find Full Text PDFStimulus-responsive mode is highly desirable for improving the precise monitoring and physiological efficacy of endogenous biomarkers (EB). However, its integrated application for visual detection and therapy is limited by inappropriate use of responsive triggers and poor delivery of EB signal-transducing agents, which remain challenging in simultaneous monitoring and noninvasive therapy of EB and EB-mediated pathological events. Target microRNA (miRNA) as controllable reaction triggers and DNAzyme as signal-transducing agent are proposed to develop target-stimulated multifunctional nanocabinets (MFNCs) for the visual tracking of both miRNA and miRNA-mediated anticancer events.
View Article and Find Full Text PDFIntroduction: The purpose of this study was to comparatively evaluate the effects of Twin-block (TB) appliance and sagittal-guidance Twin-block (SGTB) appliance on alveolar bone around mandibular incisors in growing patients with Class II Division 1 malocclusion, using cone-beam computed tomography.
Methods: The sample consisted of 25 growing patients with Class II Division 1 malocclusion (14 boys and 11 girls, mean age 11.92 ± 1.