Publications by authors named "Yujiro Nishioka"
Background: The oncologic significance of specific KRAS point mutations for patients with colorectal liver metastases (CLM) is uncertain. This study aimed to assess the prognostic impact of KRAS point mutations on patients who underwent surgery for CLM.
Methods: Patients who underwent curative-intent surgery for CLM from 2001 to 2020 were selected for the study.
Background: Gallbladder cancer is a malignancy with a highly dismal prognosis, requiring optimal surgical strategies to achieve effective outcomes. We aimed to evaluate the outcomes of our algorithm-based decision-making approach based on image T-factors and intraoperative pathology of regional lymph node metastases and the bile duct stumps in patients undergoing gallbladder cancer resection.
Methods: A prospectively maintained database of patients who underwent gallbladder cancer resection between April 2001 and June 2022 was reviewed.
Background: Robotic trocars are recommended to be placed 6-8 cm apart, and assistant trocars are placed 7 cm away from the horizontal line of the robotic trocar placement. However, adhering to these rules may be difficult, particularly in lean patients. This study aims to demonstrate our standardized simple trocar placement, 5-cm single umbilicus incision + 2 ports for robotic liver resection (RLR) and robotic pancreaticoduodenectomy (RPD).
View Article and Find Full Text PDFArticle Synopsis
- A case study is presented of a patient who developed fatal hyperacute liver failure from varicella zoster virus after a liver transplant, marking the first report of such an occurrence in liver transplant patients.
- Despite being positive for the virus, the patient was unvaccinated and undergoing immunosuppression, leading to quick deterioration of liver function within days post-surgery.
- The study highlights the difficulty in diagnosing hyperacute liver failure due to the absence of skin lesions and rapid progression of the disease, which has only been reported in a few other solid organ transplant cases.
Aim: Portal vein tumor thrombus (PVTT) in hepatocellular carcinoma (HCC) is an essential therapeutic and prognostic factor. E-cadherin plays a crucial role in adhesive properties and intercellular interaction in various cancer tissues, including HCC, but the expression profile and functional contribution of E-cadherin in PVTT remain unknown. This study aimed to analyze the expression of E-cadherin in the main tumor tissue and PVTT tissue of HCC, and evaluate the functional roles of E-cadherin in PVTT formation.
View Article and Find Full Text PDFAim: Constitutional indocyanine green (ICG) excretory defects must be distinguished when assessing liver function. The absence of OATP1B3 expression due to homogenous alterations in the SLCO1B3 gene has been recently reported to induce ICG excretory defects; however, its association with the clinical examinations and the clinical implications of heterogeneous SLCO1B3 gene alteration remain unclear.
Methods: OATP1B3 expression was evaluated in 49 patients who underwent hepatectomy after evaluation of the ICG retention rate at 15 min (ICGR15) and technetium-99 m-galactosyl serum albumin (99mTc-GSA) hepatic scintigraphy.
Article Synopsis
- Tumors invading major abdominal veins complicate surgical procedures, leading to challenges in resection and reconstruction of veins like the inferior vena cava and portal vein.
- A systematic literature review analyzed 106 papers to assess the oncologic benefits and technical aspects of these complicated procedures, revealing that aggressive hepatic vein resection's effectiveness remains uncertain.
- While techniques for venous reconstruction, such as autologous grafts and synthetic materials, have been explored, challenges like size mismatch and lower patency rates highlight the need for further research and improvement in surgical practices.
Article Synopsis
- - The study compares manual liver volumetry on CT images to two software programs, SYNAPSE and syngo.via, in 30 patients who had right hepatectomy, focusing on accuracy, time efficiency, and learning curves.
- - Results showed that the manual method produced lower future liver remnant (FLR) measurements and was less reproducible compared to the software methods, with SYNAPSE being the quickest.
- - The findings suggest that using three-dimensional simulation software improves liver volumetry efficiency and accuracy, aiding less experienced physicians in learning the process more effectively.
Background: For patients with synchronous liver metastases (LM) from rectal cancer, a consensus on surgical sequencing is lacking. We compared outcomes between the reverse (hepatectomy first), classic (primary tumor resection first), and combined (simultaneous hepatectomy and primary tumor resection) approaches.
Methods: A prospectively maintained database was queried for patients with rectal cancer LM diagnosed before primary tumor resection who underwent hepatectomy for LM from January 2004 to April 2021.
[Current strategy of surgical treatment for hepatocellular carcinoma: hepatectomy and liver transplantation].
Nihon Shokakibyo Gakkai Zasshi
January 2023
Background: We assessed whether or not covalently closed circular DNA (cccDNA) levels in the background liver influence the recurrence of hepatocellular carcinoma (HCC) in patients with resolved hepatitis B virus (HBV) infection.
Methods: Among 425 patients who underwent initial hepatectomy for HCC between 2010 and 2018, a retrospective review was performed in 44 with resolved HBV infection. The clinicopathologic characteristics were analyzed for correlation with tumor recurrence.
Objective: Noninvasive intraductal papillary mucinous neoplasms (IPMNs) theoretically do not metastasize. The purpose of this study is to preoperatively distinguish invasive carcinomas associated with IPMN from noninvasive IPMN.
Methods: A total of 131 patients who underwent surgical resection for IPMN were retrospectively analyzed to identify the predictors of invasive carcinoma, based on the International Association of Pancreatology Consensus Guidelines.
Objective: To evaluate the association of perioperative ctDNA dynamics on outcomes after hepatectomy for CLM.
Summary Background Data: Prognostication is imprecise for patients undergoing hepatectomy for CLM, and ctDNA is a promising biomarker. However, clinical implications of perioperative ctDNA dynamics are not well established.
Background: Micrometastases, defined as microscopic cancer cells spatially separated from the macroscopically evident metastasis, are identified in 24% to 56% of resected colorectal liver metastases (CLMs). Somatic gene mutations have emerged as independent prognostic factors in CLM. This study aimed to determine the prognostic impact and risk factors for the presence of micrometastases, including somatic gene mutations.
View Article and Find Full Text PDFArticle Synopsis
- The study investigated the survival outcomes of patients with multiple colorectal liver metastases (CLMs) who showed mixed pathologic responses to preoperative chemotherapy before undergoing surgery.
- Among 444 patients analyzed, 24% exhibited a mixed response, which resulted in median recurrence-free and overall survival rates that were comparable to those with major responses but better than those with minor responses.
- The findings suggest that having a mixed pathologic response is linked to a significant reduction in the risk of death compared to those with minor responses, highlighting the importance of this classification in predicting patient outcomes.
Background: Circulating tumor DNA (ctDNA) is a promising biomarker for patients undergoing hepatectomy for colorectal liver metastases (CLM). We hypothesized that post-hepatectomy ctDNA detection would identify patients at highest risk for early recurrence of CLM.
Study Design: Patients with CLM who underwent curative-intent hepatectomy with ctDNA analysis within 180 days postoperatively (1/2013 and 6/2020) were included.
The histological growth pattern of liver metastases (desmoplastic, pushing, and replacement patterns) at the tumor-liver parenchymal interface is a prognostic factor in patients with colorectal cancer. However, data regarding its association with the primary tumor characteristics and molecular alterations are limited. This study evaluated the histological growth pattern in 136 cases of colorectal cancer liver metastases without preoperative treatment, comparing it with the clinicopathological features of the primary tumor.
View Article and Find Full Text PDFBackground: The effect of bevacizumab plus mFOLFOX6 on downsizing of liver metastases for curative resection has not been well assessed for patients with advanced colorectal liver metastases (CRLMs). This multicenter phase II trial aimed to examine the efficacy and safety of bevacizumab plus mFOLFOX6 for advanced CRLMs harboring mutant-type KRAS.
Methods: Patients with advanced CRLMs (tumor number of ≥5 and/or technically unresectable) harboring mutant-type KRAS were included.
Preoperative portal vein embolization: a comparison of ethanol and coils ethanol alone.
Minim Invasive Ther Allied Technol
August 2022
Purpose: To compare the efficacy and safety of preoperative portal vein embolization (PVE) with ethanol and coils versus ethanol alone.
Material And Methods: Between April 2014 and May 2019, 45 patients underwent right preoperative PVE with ethanol and coils ( = 19; EthCo group) or ethanol alone ( = 26; Eth group).
Results: The change in % future liver remnant (FLR) was not significantly different between the EthCo and Eth groups (11.
Background: We evaluated the associations of surgical margin status and somatic mutations with the incidence of local recurrence (LR) and oncologic outcomes in patients undergoing R0-intent (microscopically negative margin) resection of colorectal liver metastases (CLM).
Methods: Patients with CLM who underwent initial R0-intent resection and analysis of tumor tissue using next-generation sequencing during 2001-2018 were analyzed. Recurrences were classified as LR (at the resection margin), other intrahepatic recurrence, or extrahepatic recurrence.
Objectives: In two-stage hepatectomy for bilateral liver metastases, patient dropout between stages is a major issue. We recently proposed a novel approach of fast-track two-staged hepatectomy (FT-TSH), in which patients undergo concurrent first-stage hepatectomy (FSH) with portal vein embolization (PVE) in a hybrid interventional radiology surgical suite. However, its efficacy remains unclear.
View Article and Find Full Text PDF