Publications by authors named "Yujing Mao"
Antibiotic abuse has led to an increasingly serious risk of antimicrobial resistance, developing alternative antimicrobials to combat this alarming issue is urgently needed. Rhesus theta defensin-1 (RTD-1) is a theta-defensin contributing to broad-spectrum bactericidal activity via the mechanisms of membrane perturbation. Intriguingly, human defensin-6 (HD6), an enteric defensin secreted by Paneth cells without direct bactericidal effect, could self-assembled into fibrous networks to trap enteric pathogens for assistance of innate immunity.
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- The study investigates gene expression patterns in Systemic Lupus Erythematosus (SLE) patients, focusing on those in remission and identifying abnormal pathways.
- Researchers performed RNA-sequencing on blood samples from patients with varying disease activity and analyzed the differences in gene expression, finding that certain immune responses remained active even during remission.
- The results suggest potential targets for drug repurposing to prevent disease flare-ups by understanding persistent gene signatures in remission patients, which could improve treatment approaches.
Article Synopsis
- - The study explored the genetic underpinnings of septic shock (SS) by analyzing gene expression in 282 SS samples and comparing them with 79 normal controls, identifying three molecular subtypes based on their gene profiles.
- - Each subtype displayed distinct patterns of differentially expressed genes (DEGs), with type I having 7361 DEGs, type II with 5594, and type III with 7159, highlighting the complexity of the disease.
- - The research found specific gene modules correlated with patient demographics like gender and age, and showed that the biological functions and pathways involved in septic shock vary significantly among these gene modules.
Introduction: Morchella has become a research hotspot because of its wide distribution, delicious taste, and phenotypic plasticity. The Qinghai-Tibet Plateau subkingdoms (QTPs) are known as the cradle of Ice age biodiversity. However, the diversity of Morchella in the QTPs has been poorly investigated, especially in phylogenetic diversity, origin, and biogeography.
View Article and Find Full Text PDFObjectives: To identify novel genetic loci associated with systemic lupus erythematosus (SLE) and to evaluate potential genetic differences between ethnic Chinese and European populations in SLE susceptibility.
Methods: A new genome-wide association study (GWAS) was conducted from Jining, North China, on 1506 individuals (512 SLE cases and 994 matched healthy controls). The association results were meta-analysed with existing data on Chinese populations from Hong Kong, Guangzhou and Central China, as well as GWAS results from four cohorts of European ancestry.
[Effects of macrophage migration inhibitory factor on early acute pancreatitis].
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
February 2020
Objective: To investigate the value of macrophage migration inhibitor factor (MIF) in early severe acute pancreatitis (SAP).
Methods: (1) Animal experiment: according to the random number table method, 24 male Sprague-Dawley (SD) rats were divided into Sham group and SAP 3, 6 and 12 hours groups, with 6 rats in each group. SAP rat model was prepared by injecting 5% sodium taurocholate via the retrograde cholangiopancreatic duct.
[Analysis of infection-related mortality after allogeneic hematopoietic stem cell transplantation in patients with refractory/relapse acute leukemia].
Nan Fang Yi Ke Da Xue Xue Bao
September 2012
Objective: To investigate infection-related mortality (IRM) after allogeneic hematopoietic stem cell transplantation in patients with refractory/relapse acute leukemia.
Methods: We conducted a retrospective analysis of 127 patients with refractory/relapse acute leukemia and investigated the incidence, causes and risk factors of IRM.
Results: Sixty-seven of the patients died after the transplantation.