Publications by authors named "Yujing Liu"

The amphipod Hirondellea gigas is a dominant species inhabiting the deepest part of the ocean (∼6,800-11,000 m), but little is known about its genetic adaptation and population dynamics. Here, we present a chromosome-level genome of H. gigas, characterized by a large genome size of 13.

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All-solid-state batteries (ASSBs) represent a transformative advancement in energy storage, distinguished by their superior safety and energy density. However, the sustainable development of ASSBs depends critically on the effective recycling of solid electrolytes and electrode materials from spent batteries, which poses significant challenges. Here, we present a facile and high-value-added carbothermal strategy for recycling spent poly(ethylene oxide) (PEO)-based electrolytes.

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The ability to wait before responding is crucial for many cognitive functions, including reaction time tasks, where one must resist premature actions before the stimulus and respond quickly once the stimulus is presented. However, the brain regions governing waiting remain unclear. Using localized excitotoxic lesions, we investigated the roles of the motor cortex (MO) and sensorimotor dorsolateral striatum (DLS) in male rats performing a conditioned lever release task with variable delays.

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Background: Cervical carcinoma (CC) poses significant health challenges, with its pathogenesis not fully understood. While ubiquitin specific peptidase 43 (USP43) is implicated in various cancers, its role in CC and regulation of the Hippo/Transcriptional Co-Activator With PDZ-Binding Motif (TAZ) pathway remain unexplored. This study examines USP43's impact on CC progression and its interaction with TAZ.

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: Colorectal cancer (CRC) frequently co-occurs with intestinal system diseases (ISDs), yet their molecular interplay remains poorly understood. We employed a comprehensive bioinformatics approach to elucidate shared genetic signatures and pathways between CRC and ISDs. : We systematically analyzed 12 microarray and RNA-seq datasets encompassing 989 samples across seven ISDs and CRC.

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In this study, we developed a novel strategy for effective bacteria capture, elimination, and detection. The aptamer of Staphylococcus aureus (S. aureus) was immobilized on FeO NPs and partly hybridized with the T strand, which exhibited good bacterial capture efficiency.

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This study aimed to determine whether lobectomy is appropriate for the long-term prognosis of 1-4-cm-sized differential thyroid cancer (DTC). This retrospective study included 2,178 patients with 1-4-cm DTC treated via thyroid lobectomy (LT) or total or near-total thyroidectomy (TT) and who were followed up for at least 3 years. The primary endpoint was a structural incomplete response, which was confirmed via imaging with or without a positive histological or cytological examination.

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The coordination development of the Water-Energy-Food complex system (WEF CS) is vital to realizing the Sustainable Development Goals of the United Nations. However, the existing research ignores the influence of external environment, and it is not clear which dimension is the key driving mechanism for coordinated development of WEF CS. Herein, it built a theoretical framework of "system unit-nexus-natural environment" WEF CS based on the logical framework of "unit-nexus-external environment", and adopted Dagum Gini coefficient, coupling coordination degree, and grey correlation models to explore the sustainable development ability of water resource, energy resource and food resource of the Yellow River Basin (YRB).

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Article Synopsis
  • - Colorectal cancer (CRC) progresses through stages from normal cells to adenomas and then to invasive cancer, involving various molecular changes, including extrachromosomal circular DNAs (ecDNAs), although their exact roles in CRC are not fully understood.
  • - Researchers used Circle-Sequencing and whole transcriptomic sequencing to analyze circular DNAs and transcriptomes in healthy individuals and patients with adenomas and CRC, revealing that specific circular DNAs influence oncogene expression and are linked to immune response and cell cycle pathways.
  • - Among the findings, chr8 showed significant up-regulation during CRC progression and was associated with poor prognosis in a separate cohort, suggesting it could serve as a valuable biomarker and potential therapeutic target for CRC treatment
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The self-assembled monolayer (SAM) technique, known for its customizable molecular segments and active end groups, is widely recognized as a powerful tool for regulating the interfacial properties of high-energy-density lithium metal batteries. However, it remains unclear how the degree of long-range order in SAMs affects the solid electrolyte interphase (SEI). In this study, we precisely controlled the hydrolysis of silanes to construct monolayers with varying degrees of long-range order and investigated their effects on the SEI nanostructure and lithium anode performance.

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  • Immune checkpoint blockade (ICB) therapy shows promise for treating advanced cancers, but its effectiveness is often limited due to low response rates.
  • Researchers developed a nanoparticle called TPM1 that specifically targets and binds to PD-L1 on tumor cell surfaces, altering its structure to enhance PD-L1 aggregation.
  • In tests with mice, TPM1 demonstrated prolonged retention in tumors and improved anti-cancer effects by activating CD8 T cells, suggesting it could boost the efficacy of ICB therapy.
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  • The study focuses on the growth of secondary hair follicles (SHFs) in cashmere goats, which undergoes distinct phases—telogen, anagen, and catagen—during which proteins play vital roles.
  • Researchers conducted proteome sequencing and experiments on skin tissues from goats at different SHF growth stages, identifying FKBP10 and FBN2 as key proteins influencing SHF cycles.
  • Findings revealed that the expression of FKBP10, FBN2, and other related proteins was higher in the active growth stage (anagen) and lower during rest (telogen), suggesting their potential to enhance cashmere production and providing insights for future research.
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Gender recognition is an important part of the duck industry. Currently, the gender identification of ducks mainly relies on manual labor, which is highly labor-intensive. This study aims to propose a novel method for distinguishing between males and females based on the characteristic sound parameters for day-old ducks.

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Epigenetics, particularly deacetylation, plays a critical role in tumorigenesis as many carcinogens are under tight control by post-translational modification. HDAC6, an important and special histone deacetylase (HDAC) family member, has been indicated to increase carcinogenesis through various functions. Recent studies demonstrated the effects of HDAC6 inhibitors in mitotic arrest, however, detailed mechanisms still remain unknown.

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  • Scientists found a lot of tiny living things called microbes in the ocean, gathering over 43,000 genomes to study.
  • They discovered new tools that could help fight bacteria, like a special CRISPR system and some substances that kill germs.
  • This research shows how the variety of microbes in the ocean can help us create new technology and medicine that can benefit us in the future.
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  • Cadmium (Cd) is a harmful heavy metal that pollutes soil and negatively affects plant growth, while methyl jasmonate (MeJA) is a phytohormone that helps plants resist heavy-metal toxicity.
  • Research explored how different levels of MeJA can affect the response of the plant Cosmos bipinnatus to Cd stress.
  • Findings revealed that low levels of MeJA enhance seedling growth by reducing Cd transport to shoots and boosting antioxidant enzyme activity, as well as increasing cell wall components that bind Cd.
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Additive manufacturing (AM) is a technology that builds parts layer by layer. Over the past decade, metal additive manufacturing (AM) technology has developed rapidly to form a complete industry chain. AM metal parts are employed in a multitude of industries, including biomedical, aerospace, automotive, marine, and offshore.

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Living organisms have developed a miraculous biomineralization strategy to form multistage organic-inorganic composites through the orderly assembly of hard/soft substances, achieving mechanical enhancement of materials from the nanoscale to the macroscale. Inspired by biominerals, this study used polydopamine (PDA) coating as a template to induce the growth of hydroxyapatite (HAP) on the surface of carbon fibers (CFs) for enhancing the interfacial properties of the CF/epoxy resin composites. This polydopamine-assisted hydroxyapatite formation (pHAF) biomimetic mineralization strategy constructs soft/hard ordered structure on the CF surface, which not only improves the chemical reaction activity of the CFs but also increases the fiber surface roughness.

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Hybrid materials with a rational organic-inorganic configuration can offer multifunctionality and superior properties. This principle is crucial but challenging to be applied in designing the solid electrolyte interphase (SEI) on lithium metal anodes (LMAs), as it substantially affects Li transport from the electrolyte to the anode. Here, an artificial SEI with an ultrahigh fluorine content (as high as 70.

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Single-cell technologies allow us to gain insights into cellular processes at unprecedented resolution. In stem cell and developmental biology snapshot data allow us to characterize how the transcriptional states of cells change between successive cell types. Here, we show how approximate Bayesian computation (ABC) can be employed to calibrate mathematical models against single-cell data.

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Lipases are increasingly attracting attention in green and sustainable biodiesel production. Currently, the research emphasis lies in immobilizing unstable lipase onto carriers to enhance its performance. Polyacrylonitrile fiber (PANF) is considered to be a promising material for lipase immobilization due to its excellent properties.

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Sonic hedgehog (Shh) is a component of the Hedgehog signaling pathway, playing an important role in regulating cell proliferation, differentiation, apoptosis, and the repair of damaged organisms. To further clarify the expression pattern of Shh gene in the secondary hair follicle growth cycle of cashmere goats and its mechanism of action on secondary hair follicle papilla cells, and improve cashmere quality, in this study, we took Inner Mongolia Albas white cashmere goats as the research objects and collected skin samples at different growth stages to obtain secondary hair follicles, detected Shh and its gene expression by RT-qPCR, Western blot, immunohistochemistry, and other techniques, while we also cultured DPCs in vitro. Shh gene overexpression and interference vectors were constructed, and the effects of Shh gene on the proliferation and apoptosis of DPCs were studied through cell transfection technology.

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  • - The study investigates the link between brain activity asymmetry, gray matter differences, and severity in early-stage Parkinson's disease (PD) using a sample of 93 patients compared to healthy controls.
  • - Researchers found that both PD subgroups exhibited reduced functional connectivity in various brain regions, with more significant reductions in the moderate group, indicating a relationship between brain activity changes and disease progression.
  • - The findings suggest that as PD severity increases, asymmetrical brain activity becomes more pronounced, indicating that voxel-mirrored homotopic connectivity (VMHC) is a valuable measure for assessing early-stage PD severity.
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Recently emerging lithium ternary chlorides have attracted increasing attention for solid-state electrolytes (SSEs) due to their favorable combination between ionic conductivity and electrochemical stability. However, a noticeable discrepancy in Li-ion conductivity persists between chloride SSEs and organic liquid electrolytes, underscoring the need for designing novel chloride SSEs with enhanced Li-ion conductivity. Herein, an intriguing trigonal structure (i.

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The pursuit of high energy density in lithium batteries has driven the development of efficient electrodes with low levels of inactive components. Herein, a facile approach involving the use of π-π stacked nigrosine@carbon nanotube nanocomposites as an all-in-one additive for a LiFePO cathode has been developed. This design significantly reduces the proportion of inactive substances within the cathode, resulting in a battery that exhibits a high specific capacity of 143 mAh g at a 1 C rate and shows commendable cyclic performance.

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