Publications by authors named "Yujing Kong"

Manipulating cell-cell interactions is of great significance in cell communication and cell-based therapies. Although efforts have been made to construct cell-cell assembly by stimuli-responsive host-guest interactions, controllable cell-cell interactions by near-infrared (NIR) light triggered reversible assembly remain a challenge. Herein, we develop a NIR-controlled system based on β-cyclodextrin (β-CD) modified upconversion nanoparticles (UCNPs) for reversible and noninvasive manipulation of cell assembly and disassembly, which is realized by host-guest interactions between /-photoisomerization of arylazopyrazole (AAP) and β-CD under the NIR irradiation.

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Background: Circular RNA circ_0004771 (termed circNRIP1) was identified by RNA-Seq previously and was elevated in papillary thyroid carcinoma (PTC) tissues. A series of studies also showed that circNRIP1 was upregulated in some tumors and could promote the malignant progression of tumors. This research intended to focus on the role of circNRIP1 in PTC progression and explore the mechanisms underlying circNRIP1 functions.

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Precise modulation of pH in living cells plays a vital role in the study of many diseases, such as cancer and rheumatoid arthritis. Here, a series of imine-linked covalent organic frameworks (COFs) were rationally designed and developed for pH sensing in tumor cells and zebrafish. Four monomers were chosen to synthesize COFs (COF-COF) with different p by a simple orthogonal combination through condensation reaction.

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Article Synopsis
  • The study introduced a novel near-infrared (NIR) light-controlled DNA walker system designed for sensitive imaging of rare microRNA (miRNA) in living cells, powered by endogenous ATP.
  • This system features a stable design with low fluorescent background noise, enhancing the clarity of bioimaging.
  • The use of upconversion nanoparticles (UCNPs) allows for the conversion of NIR light to UV light, enabling the DNA walker to autonomously navigate in living cells for precise imaging of miRNA across various cell lines.
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An efficient palladium-catalyzed Suzuki coupling of 1,1-diarylmethyl-trimethylammonium triflates with arylboronic acids is reported. This reaction offers a novel approach to triarylmethane derivatives in good to excellent yields with the palladium-catalyzed C-N bond cleavage as the key feature. Broad substrate scope regarding both reaction partners are observed.

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