Reduction of cardiovascular complications during delivery hospitalization in patients undergoing bariatric procedures.

Background: The global surge in obesity presents a significant health challenge, leading to increased adoption of bariatric surgery as an intervention. However, the correlation between bariatric surgery and cardiovascular outcomes during subsequent pregnancies remains unclear. The aim of our study was to determine the prevalence of cardiovascular complications during delivery hospitalizations in patients with bariatric procedure.

Decoding the biology and clinical implication of neutrophils in intracranial aneurysm.

Objective: Abundant neutrophils have been identified in both ruptured and unruptured intracranial aneurysm (IA) domes, with their function and clinical implication being poorly characterized.

Materials And Methods: We employed single-cell RNA sequencing (scRNA-Seq) datasets of both human and murine model, and external bulk mRNA sequencing datasets to thoroughly explore the features and functional heterogeneous of neutrophils infiltrating the IA dome.

Results: We found that both unruptured and ruptured IA dome contain a substantial population of neutrophils, characterized by FCGR3B, G0S2, CSF3R, and CXCR2.

Classification models for Tobacco Mosaic Virus and Potato Virus Y using hyperspectral and machine learning techniques.

Tobacco Mosaic Virus (TMV) and Potato Virus Y (PVY) pose significant threats to crop production. Non-destructive and accurate surveillance is crucial to effective disease control. In this study, we propose the adoption of hyperspectral and machine learning technologies to discern the type and severity of tobacco leaves affected by PVY and TMV infection.

Maternal and perinatal outcomes of pregnant patients with colorectal cancer: a population-based study.

Purpose: This study aimed to investigate the maternal and perinatal outcomes of pregnant patients with CRC using a large population-based database.

Methods: A retrospective cohort study was conducted using the Nationwide Inpatient Sample (NIS) from 2009 to 2019. Pregnant patients with and without CRC were compared for demographic characteristics, comorbidities, maternal and perinatal outcomes, and hospital burden.

Effects of transarterial chemoembolization on the immunological function of patients with hepatocellular carcinoma.

The present study aimed to investigate the effects of transarterial chemoembolization (TACE) on the immune function of patients with hepatocellular carcinoma (HCC). A total of 114 patients with HCC were selected and their peripheral blood was collected before and 1 month after TACE treatment. Flow cytometry and reverse transcription-quantitative PCR were performed to analyze the changes in immune function in patients before and after treatment.

Association Between , , Gene Polymorphisms and Risk of Hypertensive Disorders of Pregnancy in the Northern Chinese Population.

The objective of this study was to investigate the role of endothelial nitric oxide synthase (eNOS), matrix metalloproteinases (MMP)-9, and Bcl2-associated oncogene 6 (BAG-6) gene polymorphisms, as well as the combined role of single nucleotide polymorphisms (SNPs) in hypertensive disorders of pregnancy (HDP) patients. This case-control study consisted of women with 326 HDP and 312 healthy pregnant controls. Multiplex PCR combined with next-generation sequencing method was used for determination of gene polymorphisms.

Production of azimuthally polarized beam with helical phase by use of the axicons and annular glass cylinder.

In this paper, we proposed a method for producing the azimuthally polarized vector beam experimentally. The experimental setup includes two of the same axicons and one annular glass cylinder. The top angles of the two axicons were placed facing each other and the annular cylinder was set among the two axicons.

[Rule of acupoint combination in acupuncture treatment of hiccup: a study based on complex network analysis].

Objective: To explore the rule of acupoint combination in acupuncture treatment of hiccups.

Methods: Original research articles on acupuncture treatment of hiccup were collected from databases of CNKI, Wanfang, VIP, and Pubmed by using key words of "hiccup", "acupuncture" "diaphragmatic spasm" "body acupuncture" "filiform needle" and "electroacupuncture". According to our inclusive and exclusive criteria, the collected data were extracted to establish an acupuncture prescription database for hiccup.

Generation of propagation-invariant vector beams with square array by use of 2D binary phase mask and pentagonal prism.

In this paper, we realize the generation of propagation-invariant vector beams with square array by use of a 2D binary phase mask and pentagonal prism in a typical Mach-Zehnder optical system. The binary phase mask set in the optical system is perpendicular to the optical axis, and its periodic orientation is 45° relative to the horizontal and vertical directions. One polarizer was used to produce the linearly polarized beam with the angle of 45° relative to the horizontal and vertical directions.

Genome-wide identification of cancer-specific alternative splicing in circRNA.

Circular RNA (circRNA) is a group of RNA families generated by RNA circularization, which was discovered ubiquitously across different cancers. However, the internal structure of circRNA is difficult to determine due to alternative splicing that occurs in its exons and introns. Furthermore, cancer-specific alternative splicing of circRNA is less likely to be identified.

CVm6A: A Visualization and Exploration Database for m⁶As in Cell Lines.

N6-methyladenosine (m⁶A) has been identified in various biological processes and plays important regulatory functions in diverse cells. However, there is still no visualization database for exploring global m⁶A patterns across cell lines. Here we collected all available MeRIP-Seq and m⁶A-CLIP-Seq datasets from public databases and identified 340,950 and 179,201 m⁶A peaks dependent on 23 human and eight mouse cell lines respectively.

Antagonistic effects of selenium on lead-induced autophagy by influencing mitochondrial dynamics in the spleen of chickens.

Lead (Pb) may damage the immune function in human and animal. Selenium (Se) has antagonistic effects on Pb. In our study, brown layer chickens were randomly allocated to control group, Se group (1 mg/kg Se), Se+Pb group (1 mg/kg Se and 350 mg/kg Pb), and Pb group (350 mg/kg Pb).

Quasi-steady-state air plasma channel produced by a femtosecond laser pulse sequence.

A long air plasma channel can be formed by filamentation of intense femtosecond laser pulses. However, the lifetime of the plasma channel produced by a single femtosecond laser pulse is too short (only a few nanoseconds) for many potential applications based on the conductivity of the plasma channel. Therefore, prolonging the lifetime of the plasma channel is one of the key challenges in the research of femtosecond laser filamentation.

Tyrosine-protein phosphatase non-receptor type 12 expression is a good prognostic factor in resectable non-small cell lung cancer.

Tyrosine-protein phosphatase non-receptor type 12 (PTPN12) has been considered to be a tumor suppressor in human cancer, but its clinical and prognostic significance in non-small cell lung cancer (NSCLC) has not been well elucidated.A retrospective analysis of 215 patients with surgically resected NSCLCs from Sun Yat-Sen University Cancer Center between April 2002 and March 2005 was performed using immunohistochemistry and Western Blot to analyze PTPN12 expression. The association between PTPN12 expression and patient survival was investigated.

Expression of Cystatin SN significantly correlates with recurrence, metastasis, and survival duration in surgically resected non-small cell lung cancer patients.

Cystatin SN has been considered to be involved in human cancer, but its clinical significance in non-small cell lung cancer (NSCLC) has not been elucidated. The aim of this study was to evaluate the clinical value of Cystatin SN expression in patients with surgically resected NSCLCs. A retrospective analysis of 174 patients with surgically resected NSCLCs from April 2002 to March 2005 was performed with immunohistochemistry and fluorescence in situ hybridization to analyze the protein expression and amplification of Cystatin SN.

Nanopore back titration analysis of dipicolinic acid.

Here, we report a novel label-free nanopore back titration method for the detection of dipicolinic acid, a marker molecule for bacterial spores. By competitive binding of the target analyte and a large ligand probe to metal ions, dipicolinic acid could be sensitively and selectively detected. This nanopore back titration approach should find useful applications in the detection of other species of medical, biological, or environmental importance if their direct detection is difficult to achieve.

Real-time label-free measurement of HIV-1 protease activity by nanopore analysis.

A label-free method for the measurement of the activity of HIV-1 protease is developed by real-time monitoring of the cleavage of a peptide substrate by HIV-1 protease in a nanopore. The method is rapid and sensitive: picomolar concentrations of HIV-1 protease could be detected in ~10 min. Simulated clinical samples are analyzed, and the activity of HIV-1 protease could be accurately detected.

Nanopore biosensor for label-free and real-time detection of anthrax lethal factor.

We report a label-free real-time nanopore sensing method for the detection of anthrax lethal factor, a component of the anthrax toxin, by using a complementary single-stranded DNA as a molecular probe. The method is rapid and sensitive: sub-nanomolar concentrations of the target anthrax lethal factor DNA could be detected in ∼1 min. Further, our method is selective, which can differentiate the target DNA from other single-stranded DNA molecules at the single-base resolution.

Generation of arbitrary vector beams with cascaded liquid crystal spatial light modulators.

A flexible approach is presented to generate vector beams with arbitrary polarization and complex amplitude by means of two cascaded transmissive liquid crystal spatial light modulators (LCSLMs). The configuration of the cascaded LCSLM system and its modulation characteristic are introduced. Theoretical analysis and experimental demonstration prove that the system in combination with a double-pass computer-generated hologram and a black-and-white pattern can generate vector beams with arbitrary polarization and complex amplitude by respectively controlling the complex amplitudes of two orthogonal polarization components of the beams.

Radial Hilbert transform with the spatially variable half-wave plate.

We analyzed the point spread function (PSF) of the typical 4f optical image processing system by use of a spatially variable half-wave plate as the spatial filter and found that the PSF is an elementary vector beam. Theoretical analysis and real experiments show that the optical system can be used for a radially symmetric Hilbert transform that permits two-dimensional edge enhancement as the spiral phase plate. This kind of radial Hilbert transform is useful for image processing because it can enhance the edges of an input image selectively by exerting a polarization analyzer before the output plane.

Nanopore detection of copper ions using a polyhistidine probe.

We report a stochastic nanopore sensing method for the detection of Cu(2+) ions. By employing a polyhistidine molecule as a chelating agent, and based on the different signatures of the events produced by the translocation of the chelating agent through an α-hemolysin pore in the absence and presence of target analytes, trace amounts of copper ions could be detected with a detection limit of 40 nM. Importantly, although Co(2+), Ni(2+), and Zn(2+) also interacts with the polyhistidine molecule, since the event residence times and/or blockage amplitudes for these metal chelates are significantly different from those of copper chelates, these metal ions do not interfere with Cu(2+) detection.

Nanopore stochastic detection: diversity, sensitivity, and beyond.

Nanopore sensors have emerged as a label-free and amplification-free technique for measuring single molecules. First proposed in the mid-1990s, nanopore detection takes advantage of the ionic current modulations produced by the passage of target analytes through a single nanopore at a fixed applied potential. Over the last 15 years, these nanoscale pores have been used to sequence DNA, to study covalent and non-covalent bonding interactions, to investigate biomolecular folding and unfolding, and for other applications.

Overexpression of hTERT in potentially malignant colorectal laterally spreading tumors.

Human telomerase reverse transcriptase (hTERT) is the main subunit of the core enzyme telomerase, which consists of three subunits. Telomeres are essential for chromosomal stability and integrity, protecting the ends of chromosomes from degradation and preventing chromosomal end fusions and recombination. A loss of telomere function is a major mechanism for the generation of chromosomal abnormalities.

Investigation on MDR1 gene polymorphisms and its relationship with breast cancer risk factors in Chinese women.

The human multidrug resistance 1 gene (MDR1) is an important candidate gene influencing the susceptibility to various diseases, including breast cancer. The object of this study was to investigate on MDR1 gene polymorphisms and its relationship with the susceptibility to breast cancer. A total of 271 patients with breast cancer and 225 healthy controls were enrolled in this study.

Red and processed meat intake and risk of esophageal adenocarcinoma: a meta-analysis of observational studies.

Aims: Inconsistent results relating dietary red and processed meat intake and risk of esophageal adenocarcinoma (EAC) have been reported. This article summarizes and quantifies the current evidence in a meta-analysis of observational studies.

Methods: Electronic search of MEDLINE and EMBASE databases was performed to identify peer-reviewed manuscripts up to 31 May 2012.