Accuracy of a 3D printed custom resin crossbar for complete arch implant scanning: An in vitro and in vivo study.

Statement Of Problem: The accuracy of intraoral scanners for implant-supported prostheses in edentulous jaws is unclear with limited clinical evidence.

Purpose: The purpose of this in vitro and in vivo study was to evaluate the accuracy of a novel 3-dimensionally (3D) printed custom resin scanning crossbar (3D-CRC) for digital scans of complete arch implants and to provide a clinical benchmark.

Material And Methods: Four implants were placed on a completely edentulous master model for in vitro scanning.

Controllable fabrication of hierarchical porous anode for exoelectrogens internal colonization in microbial electrochemical system.

Efficient interfacial energy conversion and rapid charge transfer are crucial for application-oriented microbial electrochemical systems (MES) and depend on affordable high-performance anodes. Herein, hierarchically porous 3D anodes with controlled millimeter-scale macropores (1-2 mm) were fabricated via carbonization of phenolic foam embedded with expanded polystyrene (EPS) sacrificial templates. Optimizing EPS loading (4 wt%) and pore-sizes yielded anode L-4M, exhibiting appropriate hydrophilicity (contact angle: 60.

T1/T2 mapping as a non-invasive method for evaluating liver fibrosis based on correlation of biomarkers: a preclinical study.

Background: Given the inherent limitations of invasive biopsy and the insufficient accuracy of liver-related serum biomarkers, there is an urgent need for the development of reliable, non-invasive imaging techniques for the diagnosis of liver fibrosis. This study aims to investigate the correlation between magnetic resonance imaging (MRI) T1/T2 mapping sequences and biomarkers of collagen deposition and ongoing systemic inflammation, and to evaluate the potential of T1/T2 mapping as a non-invasive method for the accurate diagnosis of liver fibrosis.

Methods: A mouse model of carbon tetrachloride (CCl)-induced liver fibrosis was established and T1/T2 mapping were performed at different weeks of treatment.

Glymphatic system: a self-purification circulation in brain.

The glymphatic system theory introduces a new perspective on fluid flow and homeostasis in the brain. Here, cerebrospinal fluid and interstitial fluid (CSF-ISF) moves from the perivascular spaces (PVS) of arteries to those of veins for drainage. Aquaporin-4 (AQP4) plays a crucial role in driving fluid within the PVS.

Gut microbiota-derived metabolites: Potential targets for cardiorenal syndrome.

The characteristic of cardiorenal syndrome (CRS) is simultaneous damage to both the heart and kidneys. CRS has caused a heavy burden of mortality and incidence rates worldwide. The regulation of host microbiota metabolism that triggers heart and kidney damage is an emerging research field that promotes a new perspective on cardiovascular risk.

Semiquantitative studies on the correlations between the electrostatic potential of a single Dy ion and its energy barrier in the containing-Dy single molecule magnets.

Although the design of containing-Dy single molecule magnets (SMMs) based on electrostatic potential has been employed for several years, rational studies on the correlations between the electrostatic potential of a single Dy ion and its energy barriers have not been reported previously. In this work, a novel "Y"-shaped MnIII5DyIII3 complex, [MnIII5DyIII3(NO)(OCH)(L)(L')(tea)(teaH)]OH·3CHOH·2HO (1, HL = 2-methoxy-6-[()-(1-1,2,4-triazol-3-ylimino)methyl]phenol, Htea = triethanolamine and HL' = 2-hydroxy-3-methoxybenzaldehyde), was obtained through the reaction of the HL ligand, teaH, Dy(NO)·6HO and MnCl·4HO in CHOH and DMF. Structural analysis revealed that the coordination geometry of Dy1 in 1 is muffin-like (MFF-9, ), while the geometries of Dy2 and Dy3 fall among spherical capped square antiprism-like (CSAPR-9, ), spherical tricapped trigonal prism-like (TCTPR-9, ) and muffin-like (MFF-9, ).

Effect of extraction solvents on the lipid profiles and volatile compounds of fish roe phospholipids.

This study aimed to elucidate the effect of extraction solvents on the lipid profiles and volatile compounds in large yellow croaker roe phospholipids (LYPLs) with chloroform/methanol (CM), ethanol/ethanol (EE), and ethanol/hexane (EH). The results demonstrated that CM-extracted LYPLs exhibited the lowest oxidation levels, while EE-extracted LYPLs contained the highest polyunsaturated fatty acids (PUFAs) content. EH extraction was more effective for monounsaturated fatty acids (MUFAs) in LYPLs but was less effective for polar lipids.

Research on the relationship between social support and academic self-efficacy among college students: a multivariate empirical analysis.

Background: The critical role of social support in college students' academic development cannot be ignored. This study aims to analyze the interrelationships and potential mechanisms between social support, sense of security, family cultural capital and academic self-efficacy.

Methods: A multivariate moderated mediation model was constructed by surveying 1,119 college students using the Social Support Scale, the Sense of Security Scale, the Academic Self-efficacy Scale, and the Family Cultural Capital Scale.

DNA-Capturing Manganese-Coordinated Chitosan Microparticles Potentiate Radiotherapy via Activating the cGAS-STING Pathway and Maintaining Tumor-Infiltrating CD8 T-Cell Stemness.

The radiotherapy-induced release of DNA fragments can stimulate the cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon genes (cGAS-STING) pathway to prime antitumor immunity, but this pathway is expected to be less potent because of the inefficient cytosolic delivery of negatively charged DNA fragments. In this study, manganese-coordinated chitosan (CS-Mn) microparticles with selective DNA-capturing capacity are concisely prepared via a coordination-directed one-pot synthesis process to potentiate the immunogenicity of radiotherapy. The obtained CS-Mn microparticles that undergo rapid disassembly under physiological conditions can selectively bind with DNA to form positively charged DNA-CS assemblies because of the strong electrostatic interaction between linear chitosan and DNA molecules.

Dielectric polymers with mechanical bonds for high-temperature capacitive energy storage.

High-temperature capacitive energy storage demands that dielectric materials maintain low electrical conduction loss and high discharged energy density under thermal extremes. The temperature capability of dielectric polymers is limited to below 200 °C, lagging behind requirements for high-power and harsh-condition electronics. Here we report a molecular topology design for dielectric polymers with mechanical bonds that overcomes this obstacle, where cyclic polyethers are threaded onto the axles of various polyimides.

The relationship between social support and interpersonal self-efficacy among higher vocational college students: parallel mediation effects of anxiety and loneliness.

Background: There is close cooperation between higher vocational colleges and enterprises. Thus, higher vocational college students attach great importance to the internship experience in enterprises during their study period. They need to have more interaction and communication with school teachers, classmates and enterprise staffs, etc.

Liquid Metal-Based Conductive Nerve Guidance Conduit Combined With Electrical Stimulation Boosts Peripheral Nerve Repair.

The combination of nerve guide conduits (NGCs) and electrical stimulation (ES) is an effective treatment for peripheral nerve injury (PNI). Flexible conductive materials with mechanical properties similar to those of biological tissues have been shown to have better long-term biointegration and functionality than rigid conductive materials. In this study, liquid metal (LM)-based conductive polycaprolactone/gelatin/polypyrrole/LM (PCL/Gel/PPy/LM, PGPL) NGC was combined with exogenous ES to repair PNI.

Stable Luminescent Diradicals: The Emergence and Potential Applications.

Stable luminescent diradicals, characterized by the presence of two unpaired electrons, exhibit unique photophysical properties that are sensitive to external stimuli such as temperature, magnetic fields, and microwaves. This sensitivity allows the manipulation of their spin states and luminescence, setting them apart from traditional closed-shell luminescent molecules and luminescent monoradicals. As a result, luminescent diradicals are emerging as promising candidates for a variety of applications.

Recent Applications of Pillararene-Inspired Water-Soluble Hosts.

Pillararenes and their derivatives have emerged in supramolecular chemistry as unique macrocycles for applications in host-guest chemistry, materials science and biomimetics. Many variations have been conceived and synthesized in recent years and in this review, we relate progress in water-soluble versions: leaning towerarenes, extended-pillararenes, biphenarenes, helicarenes and octopusarenes. These are applied in targeted drug delivery, selective uptake and release of aromatic guests, fabrication of gold/silver and mesoporous silica nanoparticles, cell imaging, pollutant separation, biomedicine (e.

Recent progress using novel tetraphenylethylene-based macrocyclic hosts in water.

Macrocyclic structures are popular in supramolecular chemistry and have enjoyed considerable success as platforms for elaboration to container compounds and new materials. Host/guest studies in organic media have relied heavily on structures derived from crown ethers, calixarenes, cucurbiturils, resorcinarenes and pillararenes over the past decades. More recently, their water-soluble versions have been developed for potential applications in biology.

Thermal-responsive activation of engineered bacteria to trigger antitumor immunity post microwave ablation therapy.

Incomplete tumor removal after microwave ablation (MWA), a widely used hyperthermia-based therapy, can result in tumor recurrence. Herein, attenuated Salmonella typhimurium VNP20009 is engineered to release interleukin-15&interleukin-15-receptor-alpha (IL-15&IL-15Rα) in response to mildly elevated temperature. Such 15&15R@VNP colonizes in tumors upon intravenous injection, and the expression of IL-15&IL-15Rα is triggered by MWA.

Multimodel-based quantitative source apportionment and risk assessment of soil heavy metals: A reliable method to achieve regional pollution traceability and management.

To strengthen the control of pollution sources and promote soil pollution management of agricultural land, this study constructed a comprehensive source apportionment framework, which significantly improved the reliability of potential source analysis compared with the traditional single model. The spatial distribution pattern of agricultural soil heavy metals (SHMs) content in Lintong, a typical river valley city in China, was determined and the degree of contamination was evaluated. A scientific source apportionment methodological framework was constructed through correlation analysis methods together with multiple source apportionment receptor models.

Carnitine is a friend in HFpEF and foe in HFrEF.

Heart failure (HF) is a global concern, particularly HF with preserved ejection fraction (HFpEF), lacking effective treatments. Understanding the differences of metabolic profiles between HFpEF and HFrEF (heart failure with reduced ejection fraction) patients is crucial for therapeutic advancements. In this study, pseudotargeted metabolomics was employed to analyze for disparities of plasma metabolic profiles between HFpEF and HFrEF in two cohorts: discovery ( = 514) and validation ( = 3368).

The Immune Defense Response and Immune-Related Genes Expression in Infected with Decapod Iridescent Virus 1 (DIV1).

is a significant cultivated species in China. However, decapod iridescent virus 1 (DIV1), as a newly discovered crustacean-lethal virus, has resulted in significant financial losses for the industry. In order to examine the immunological response of to DIV1, we conducted transcriptome analysis of the hepatopancreas from infected with DIV1 using RNA-seq.

Electrolyte Design Enables Stable and Energy-Dense Potassium-Ion Batteries.

Free from strategically important elements such as lithium, nickel, cobalt, and copper, potassium-ion batteries (PIBs) are heralded as promising low-cost and sustainable electrochemical energy storage systems that complement the existing lithium-ion batteries (LIBs). However, the reported electrochemical performance of PIBs is still suboptimal, especially under practically relevant battery manufacturing conditions. The primary challenge stems from the lack of electrolytes capable of concurrently supporting both the low-voltage anode and high-voltage cathode with satisfactory Coulombic efficiency (CE) and cycling stability.

Mesenchymal Stem Cells-Derived Exosomal miR-223-3p Alleviates Ocular Surface Damage and Inflammation by Downregulating Fbxw7 in Dry Eye Models.

Purpose: Our previous study indicated that exosomes derived from mouse adipose-derived mesenchymal stem cells (mADSC-Exos) alleviated the benzalkonium chloride (BAC)-induced mouse dry eye model. However, the specific active molecules in mADSC-Exos that contribute to anti-dry eye therapy remain unidentified. In this study, we aimed to investigate the efficacy and mechanisms of miR-223-3p derived from mADSC-Exos in dry eye models.

Craniofacial features and incisor position design of esthetics population after orthodontic treatment.

Objectives: This study aims to provide craniofacial features and incisor position prediction models among esthetics population after orthodontic treatment.

Methods: A total of 338 patients with esthetic profiles were selected from 1 055 post-orthodontic adults based on inclusion and exclusion criteria and scored by five dental students. Mean values of cephalometric measurement were demonstrated with gender and sagittal skeletal pattern (ANB) differences assessed by generalized estimating equation.