Arabidopsis CIRP1 E3 ligase modulates drought and oxidative stress tolerance and reactive oxygen species homeostasis by directly degrading catalases.

Reactive oxygen species (ROS) plays critical roles in modulating plant growth and stress response and its homeostasis is fine tuned using multiple peroxidases. HO, a major kind of ROS, is removed rapidly and directly using three catalases, CAT1, CAT2, and CAT3, in Arabidopsis. Although the activity regulations of catalases have been well studied, their degradation pathway is less clear.

A genome-wide-level insight into the HSF gene family of Rhodomyrtus tomentosa and the functional divergence of RtHSFA2a and RtHSFA2b in thermal adaptation.

Heat shock transcription factor (HSF) is one of the most important regulatory elements in plant development and stress response. Rhohomyrtus tomentosa has many advantages in adapting to high temperature and high humidity climates, whereas its inherence has barely been elucidated. In this study, we aimed to characterize the HSF family and investigate the thermal adaptation mechanisms of R.

of Positively Regulate Thermotolerance by Transcriptionally Activating and .

Heat shock transcription factors (HSFs) are crucial components in heat stress response. However, the contribution of the HSFs governing the inherent thermotolerance in has barely been investigated. We here compared the roles of , , and in heat stress tolerance.

Activated CdS/ sulfur doped g-CN photocatalyst for dye and antibiotic degradation: Experimental and DFT verification of S-scheme heterojunction.

To alleviate situation caused by azo dyestuff and antibiotics, a series of CdS/sulfur doped carbon nitride (GCNS) S-scheme heterojunction photocatalysts have been successfully fabricated by a pretty facile solid-state diffusion (SSD) method,. Under visible light, the optimal sample called CdS/GCNS-1:2 presented the best photodegradation rate of nearly 100% over methyl orange (MO), of which the reaction constant k was about 9.67 and 5.

Identification of a novel caspase cleavage motif AEAD.

Infections of many viruses induce caspase activation to regulate multiple cellular pathways, including programmed cell death, immune signaling and etc. Characterizations of caspase cleavage sites and substrates are important for understanding the regulation mechanisms of caspase activation. Here, we identified and analyzed a novel caspase cleavage motif AEAD, and confirmed its caspase dependent cleavage activity in natural substrate, such as nitric oxide-associated protein 1 (NOA1).

Global epidemiology of severe fever with thrombocytopenia syndrome virus in human and animals: a systematic review and meta-analysis.

Background: Since the initial identification of the Severe Fever with Thrombocytopenia Syndrome (SFTS) in ticks in rural areas of China in 2009, the virus has been increasingly isolated from a diverse array of hosts globally, exhibiting a rising trend in incidence. This study aims to conduct a systematic analysis of the temporal and spatial distribution of SFTS cases, alongside an examination of the infection rates across various hosts, with the objective of addressing public concerns regarding the spread and impact of the disease.

Methods: In this systematic review and meta-analysis, an exhaustive search was conducted across multiple databases, including PubMed, Web of Science, Embase, and Medline, CNKI, WanFang, and CQVIP.

Stress-induced nuclear translocation of ONAC023 improves drought and heat tolerance through multiple processes in rice.

Drought and heat are major abiotic stresses frequently coinciding to threaten rice production. Despite hundreds of stress-related genes being identified, only a few have been confirmed to confer resistance to multiple stresses in crops. Here we report ONAC023, a hub stress regulator that integrates the regulations of both drought and heat tolerance in rice.

TFAP2A downregulation mediates tumor-suppressive effect of miR-8072 in triple-negative breast cancer via inhibiting SNAI1 transcription.

Background: Triple-negative breast cancer (TNBC) represents a highly aggressive subset of breast malignancies characterized by its challenging clinical management and unfavorable prognosis. While TFAP2A, a member of the AP-2 transcription factor family, has been implicated in maintaining the basal phenotype of breast cancer, its precise regulatory role in TNBC remains undefined.

Methods: In vitro assessments of TNBC cell growth and migratory potential were conducted using MTS, colony formation, and EdU assays.

Evaluating Childhood Overweight- and Obesity-Related Food Marketing Policies in China Using the Food-Environment Policy Index (Food-EPI).

Objective: Addressing the increasing global health issue of childhood obesity, exacerbated by pervasive food marketing, this study critically evaluated China's food marketing policies in comparison with international best practices, aiming to uncover policy content and implementation gaps and inform policy enhancement strategies.

Method: Three key indicators were utilized from the Healthy Food-Environment Policy Index (Food-EPI)'s food promotion domain. A panel of experts ( = 13) from academic institutions, China Centers for Disease Control and Prevention, and the food industry assessed the Chinese government's policy scores and implementation levels concerning food marketing.

Different Dimensions of the Home Food Environment May Be Associated with the Body Mass Index of Older Adults: A Cross-Sectional Survey Conducted in Beijing, China.

Objective: The objective of this study was to evaluate the home food environment of the elderly in Beijing and analyze its association with the body mass index (BMI) of the elderly, as well as to provide recommendations for improving the home food environment for the elderly.

Methods: This study was conducted in Beijing, China, in 2019. The participants were 1764 elderly individuals aged 65 to 80, recruited from 12 communities through a multistage stratified random sampling method.

The efficacy and safety of beinaglutide alone or in combination with insulin glargine in Chinese patients with type 2 diabetes mellitus who are inadequately controlled with oral antihyperglycemic therapy: A multicenter, open-label, randomized trial.

Background: To compare glycemic control in Chinese patients with type 2 diabetes mellitus (T2DM) whose blood glucose levels were inadequately controlled with oral antidiabetic drugs after beinaglutide alone or combined with insulin glargine (IGlar).

Methods: In this 16-week multicenter, randomized clinical trial, 68 participants randomly received beinaglutide or IGlar for 8 weeks, then the two drugs in combination for 8 weeks. The primary outcomes were the proportion of individuals achieving their glycemic target and the change in glucose variability as measured with a continuous glucose monitoring system from baseline to 8 and 16 weeks.

Magnon-photon cross-correlations via optical nonlinearity in cavity magnonical system.

We propose an alternative scheme to achieve the cross-correlations between magnon and photon in a hybrid nonlinear system including two microwave cavities and one yttrium iron garnet (YIG) sphere, where two cavities nonlinearly interact and meanwhile one of cavities couples to magnon representing the collective excitation in YIG sphere via magnetic dipole interaction. Based on dispersive couplings between two cavities and between one cavity and magnon with the larger detunings, the nonlinear interaction occurs between the other cavity and magnon, which plays a crucial role in generating quantum correlations. By analyzing the second-order correlation functions via numerical simulations and analytical calculations, the remarkable nonclassical correlations are existent in such a system, where the magnon blockade and photon antibunching could be obtainable on demand.

Identification and analysis of methylation signature genes and association with immune infiltration in pediatric acute myeloid leukemia.

Background: Acute myeloid leukemia (AML) is a common leukemia with low cure rate and poor prognosis among pediatric patients. The regulation of AML immune microenvironment and methylation remains to be explored. Pediatric and adult AML patients differ significantly in epigenetic factors, and the efficiency of treatment modalities varies between the two groups of patients.

Rift Valley Fever Virus Nucleoprotein Triggers Autophagy to Dampen Antiviral Innate Immune Responses.

Rift Valley fever virus (RVFV) is a mosquito-borne bunyavirus that causes severe and potentially fatal hemorrhagic fever in humans. Autophagy is a self-degradative process that can restrict viral replication at multiple infection steps. In this study, we evaluated the effects of RVFV-triggered autophagy on viral replication and immune responses.

Functional Analysis of Bna-miR399c- Regulatory Module Involved in Phosphorus Stress in .

Phosphorus stress is one of the important factors restricting plant growth and development, and the microRNA (miRNA) family is involved in the regulation of the response to plant nutrient stress by repressing the expression of target genes at the post-transcriptional or translational level. miR399 is involved in the transportation of phosphate in multiple plants by improving tolerance to low Pi conditions. However, the effect of miR399 on the response of low Pi stress in rapeseed ( L.

The SET domain protein PsKMT3 regulates histone H3K36 trimethylation and modulates effector gene expression in the soybean pathogen Phytophthora sojae.

Plant pathogens secrete effector proteins to overcome host immunity and promote colonization. In oomycete plant pathogens, the expression of many effector genes is altered upon infection; however, the regulatory mechanisms are unclear. In this study, we identified a su(var)3-9, enhancer of zeste, and trithorax (SET) domain protein-encoding gene, PsKMT3, that was highly induced at early infection stages in Phytophthora sojae.

Calorie restriction remodels gut microbiota and suppresses tumorigenesis of colorectal cancer in mice.

Colorectal cancer (CRC) is one of the most common cancers worldwide and the consumption of a high-calorie diet is one of its risk factors. Calorie restriction (CR) slows tumor growth in a variety of cancers, including colorectal cancer; however, the mechanism behind this remains unknown. In the present study, CR effectively reduced the tumor volume and weight in a xenograft BALB/c male nude mouse model.

Polarization-based approach for multipath interference mitigation in time-of-flight imaging.

The existence of nearby obstruction causes significant errors in depth sensing for time-of-flight cameras, namely multipath interference. A polarized time-of-flight system is established for multipath interference mitigation. Based on polarization cues and the phasor representation of time-of-flight imaging, the proposed method acquires depth maps in high accuracy when specular dominant obstruction is in path.

Bispectral phasor imaging using continuous-wave time-of-flight camera for scattering-scene depth recovery.

In scattering scenes, depth measurements are greatly distorted due to light scattering for Time-of-flight imaging. We propose a bispectral Time-of-flight system and phasor-based depth-recovery method to improve the quality of depth maps in scattering scenes. We reveal that the amplitude of scattered light is wavelength dependent while the phase measured is wavelength independent.

Establishment, immunological analysis, and drug prediction of a prognostic signature of ovarian cancer related to histone acetylation.

In recent years, epigenetic modifications have been increasingly regarded as an important hallmark of cancer. Histone acetylation, as an important part of epigenetic modification, plays a key role in the progress, treatment, and prognosis of many cancers. In this study, based on the TCGA database, we performed LASSO regression and the Cox algorithm to establish a prognostic signature of ovarian cancer associated with histone acetylation modulator genes and verified it externally in the GEO database.