Hyaluronic acid targeted and pH-responsive multifunctional nanoparticles for chemo-photothermal synergistic therapy of atherosclerosis.

Atherosclerosis is a global disease with an extremely high morbidity and fatality rate, so it is necessary to develop effective treatments to reduce its impact. In this work, we successfully prepared a multifunctional drug-loaded nano-delivery system with pH-responsive, CD44-targeted, and chemical-photothermal synergistic treatment. Dendritic mesoporous silica nanoparticles capped with copper sulfide (CuS) were synthesized an oil-water biphase stratification reaction system; these served as the carrier material and encapsulated the anticoagulant drug heparin (Hep).

Forecast of passenger car market structure and environmental impact analysis in China.

To evaluate the future passenger car market related environmental impact, first, a competitive prediction model was introduced based on Lotka-Volterra model. Further, the limit of passenger car life cycle system is extended to analyze the scale of future energy consumption and pollutant emission. The proportion of new energy passenger cars, average rate of change in the quality of passenger cars, and the share of renewable energy power generation were used as evaluation indicators to conduct scenario simulations for assessing the environmental benefits under the following policy scenarios: lightweight, electrification, and end-use energy cleaning of automobile.