Publications by authors named "Yujia Shu"
Iron is a trace element that is indispensable for the growth and development of animals. Excessive iron supplementation may lead to iron overload and elevated reactive oxygen species (ROS) production in animals, causing cellular damage. Nevertheless, the precise mechanism by which iron overload causes cell injury remains to be fully elucidated.
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- Ferroptosis is a new type of cell death linked to neurological diseases, and the study identifies sulfiredoxin-1 (SRXN1) as a key regulator that makes cells more susceptible to this process when exposed to the drug erastin.* -
- The research utilized TMT-based proteomics to show that erastin increases SRXN1 levels in HT-22 mouse hippocampal cells, and knocking down SRXN1 reduces the ferroptosis induced by erastin by lowering intracellular Fe and reactive oxygen species (ROS).* -
- The study highlights that the activation of Heme Oxygenase-1 (HO-1) is vital for SRXN1 expression and suggests that targeting the SRXN1