Application of Refrigerant Cooling in a Battery Thermal Management System under High Temperature Conditions: A Review.

Battery thermal management (BTM) is crucial for the lifespan and safety of batteries. Refrigerant cooling is a novel cooling technique that is being used gradually. As the core fluid of refrigerant cooling, refrigerants need to possess excellent properties while meeting environmental requirements.

Separation of lead-212 from natural thorium solution utilizing novel sulfonamide dibenzo-18-crown-6.

The extraction of lead-212 (Pb) from radioactive thorium (Th) waste is immensely important, as it serves to mitigate environmental risks associated with radioactive waste and provides a vital source for medical isotopes. To economically extract Pb from thorium, we synthesized a novel extractant known as 2,13-disulfonyldiethylamine dibenzo-18-crown-6 (DSADB18C6). We assessed its performance in isolating Pb(II) by employing stable lead and optimizing the parameters of the extraction system.

Synthesis and performance of guanidinium-based cationic organic polymer for the efficient removal of TcO/ReO.

Cationic organic polymers have found relatively extensive utility for TcO/ReO removal, but the harsh preparation conditions constrain their practical application. The bifunctional guanidinium-based cationic organic polymer (GBCOP) was successfully and facilely synthesized in benign conditions within 1 h. Batch experiments showed that GBCOP exhibited rapid removal kinetics (1 min, >98.

High-Temperature Pyrolysis of -Tetracosane Based on ReaxFF Molecular Dynamics Simulation.

In order to further understand the high-temperature reaction process and pyrolysis mechanism of hydrocarbon fuels, the high-temperature pyrolysis behavior of -tetracosane (CH) was investigated in this paper via the reaction force field (ReaxFF) method-based molecular dynamics approach. There are two main types of initial reaction channels for -heptane pyrolysis, C-C and C-H bond fission. At low temperatures, there is little difference in the percentage of the two reaction channels.

Gab2 mediates hepatocellular carcinogenesis by integrating multiple signaling pathways.

Our previous studies have found that Growth factor receptor-bound protein 2-associated binding protein 2 (Gab2)-a docking protein-governs the development of fatty liver disease. Here, we further demonstrate that Gab2 mediates hepatocarcinogenesis. Compared with a faint expression in -carcinoma tissue, Gab2 was highly expressed in ∼60-70% of human hepatocellular carcinoma (HCC) specimens.

Deletion of Gab2 in mice protects against hepatic steatosis and steatohepatitis: a novel therapeutic target for fatty liver disease.

Fatty liver disease is a serious health problem worldwide and is the most common cause for chronic liver disease and metabolic disorders. The major challenge in the prevention and intervention of this disease is the incomplete understanding of the underlying mechanism and thus lack of potent therapeutic targets due to multifaceted and interdependent disease factors. In this study, we investigated the role of a signaling adaptor protein, GRB2-associated-binding protein 2 (Gab2), in fatty liver using an animal disease model.

Tyrosine phosphatase Shp2 mediates the estrogen biological action in breast cancer via interaction with the estrogen extranuclear receptor.

The extranuclear estrogen receptor pathway opens up novel perspectives in many physiological and pathological processes, especially in breast carcinogenesis. However, its function and mechanisms are not fully understood. Herein we present data identifying Shp2, a SH2-containing tyrosine phosphatase, as a critical component of extranuclear ER pathway in breast cancer.

A prognosis classifier for breast cancer based on conserved gene regulation between mammary gland development and tumorigenesis: a multiscale statistical model.

Identification of novel cancer genes for molecular therapy and diagnosis is a current focus of breast cancer research. Although a few small gene sets were identified as prognosis classifiers, more powerful models are still needed for the definition of effective gene sets for the diagnosis and treatment guidance in breast cancer. In the present study, we have developed a novel statistical approach for systematic analysis of intrinsic correlations of gene expression between development and tumorigenesis in mammary gland.