Publications by authors named "Yuji Yamanaka"
Article Synopsis
- Characterizing post-translational modifications in acidic variants of therapeutic monoclonal antibodies (mAbs) is complex and remains a key research area.
- This study explored the idea that chromatographically separated acidic fractions of an IgG1 mAb could signify conformational variants by employing a refolding process.
- Findings showed that while the stepwise refolding increased the presence of acidic variants, small-angle X-ray scattering indicated minor overall conformational changes, primarily localized around aromatic amino acid regions.
Article Synopsis
- Visible particles (VPs) in liquid monoclonal antibody formulations, particularly those containing poloxamer 188 as a surfactant, can cause quality issues due to their formation from protein and silicone oil aggregations.
- This study identifies that VPs predominantly form when antibody solutions adhere to PDMS-coated stoppers in upright vials, leading to protein-PDMS aggregates that are later desorbed into the solution.
- The research evaluated various factors influencing VP formation, such as the stopper's adhesion, storage orientation, coating, vial material, and PX188's hydrophobicity, revealing that altering any of these factors can significantly impact VP development.
We investigated the elution of zinc ions (Zn) from the elastomer of rigid needle shields (RNS) attached to staked-in-needle prefilled syringes (SIN-PFS) and the physicochemical impacts of Zn on therapeutic IgG monoclonal antibody (mAb) solutions. The elution of metal ions from typical RNS elastomer under realistic buffer and storage conditions was investigated by inductively coupled plasma-mass spectrometry. Among the metal ions examined, only Zn was detected.
View Article and Find Full Text PDFSurfactants such as Poloxamer 188 (PX188) play an important role in controlling particle formation in biotherapeutic formulations due to interfacial stresses. This study demonstrates for the first time that hydrophobicity of PX188 is a potential critical material attribute (CMA) as far as control of visible particle (VP) formation is concerned. We have found that within PX188 lots satisfying pharmacopeial specifications, there is variability in material attributes such as hydrophobicity, as determined from their reversed-phase high-performance liquid chromatography profiles.
View Article and Find Full Text PDFArticle Synopsis
- Benedikt syndrome results from brain damage primarily affecting the red nucleus, leading to symptoms like oculomotor palsy on one side and involuntary movement on the opposite side, impacting daily activities.
- A case study involving a 66-year-old woman revealed that after surgery for a ruptured aneurysm, she developed oculomotor nerve palsy and later experienced involuntary movements that worsened over time but eventually improved.
- The study highlights the importance of preserving blood supply (perforators) during aneurysm treatment, as damage can lead to red nucleus ischemia and associated movement disorders, which may recover over time.
It is difficult to totally reconstruct the lip, achieving good functional and aesthetic results. There have been few reports of reconstructing complete lip defects. Moreover, upper and lower lip necrosis by purpura fulminans has not been reported.
View Article and Find Full Text PDFPerforation, bleeding, and ileus are known complications of small intestinal lymphoma and can occur either at diagnosis or during the course of treatment. Surgery is an important component in the management of these gastrointestinal complications. However, there is no consensus regarding the indications for and timing of surgery in small intestinal lymphoma.
View Article and Find Full Text PDFA man in his seventies presented with a stomach abnormality that was revealed upon physical examination.Following workup, he was diagnosed with gastric diffuse large B-cell lymphoma (DLBCL)StageII1 (Lugano staging system for gastrointestinal lymphoma) with low risk as defined by the International Prognostic Index criteria.The entire stomach showed an intense, abnormal FDG uptake by FDG-PET evaluation.
View Article and Find Full Text PDFA man in his 60s was diagnosed with gastric cancer and underwent distal gastrectomy and D2 lymph node dissection. The histological diagnosis was adenocarcinoma (T3, N1, StageIIB). He was treated with S-1 as adjuvant chemotherapy for 1 year.
View Article and Find Full Text PDFA case of abdominoplasty after removal of giant ovarian cyst.
Plast Reconstr Surg Glob Open
August 2014
Article Synopsis
- - The management of giant ovarian cysts presents multiple challenges, including issues related to inferior vena cava syndrome, potential bleeding, and maintaining abdominal integrity and appearance.
- - The specific techniques for performing abdominoplasty in patients with giant ovarian cysts have not been previously outlined.
- - In this case, a patient required the removal of 85,000 ml of fluid before undergoing surgery to address the cyst.
Article Synopsis
- In 2011, trastuzumab was approved for a quicker administration of 30 minutes if the first infusion was tolerated well.
- However, quicker infusion rates raised concerns about potential cardiovascular strain and infusion reactions.
- A study found that using a reduced volume of 100 mL saline for the infusion was well tolerated and did not increase reaction frequency, thus improving the experience for patients and healthcare providers.
[Distribution of toxicity in liver of wild pufferfish Takifugu rubripes].
Shokuhin Eiseigaku Zasshi
April 2014
Livers from wild pufferfish, Takifugu rubripes, can be described as having a smooth frontal side and an upper-region that is attached to the hepatic portal vein. Based on this description, the liver can be divided into 10 parts (L1-5 and R1-5), and in this work, the lethal potency of each part was determined by mouse bioassay. Among the raw livers from 58 individuals, all 10 parts of 16 individuals, and some parts of 4 individuals showed mouse lethality, but no toxicity was detected in any part of the liver from 22 individuals.
View Article and Find Full Text PDFBackground: The vulva is an extremely rare site for lymphangioma, a benign tumor of the lymphatic vessels. A small number of case reports have described cavernous lymphangioma involving the unilateral labium majus of young women. We report a case of cavernous lymphangiomas involving the bilateral labia minora.
View Article and Find Full Text PDFObject: The combination approach of Ommaya reservoir placement and Gamma Knife surgery (GKS) was evaluated for the treatment of large cystic metastatic brain tumors.
Methods: The medical records of 22 patients harboring 28 tumors, who underwent Ommaya reservoir placement followed by GKS for large cystic metastatic brain tumors were retrospectively reviewed. The patients' ages ranged 26 to 77 years (mean 57.