Publications by authors named "Yuji Tezuka"
Article Synopsis
- The study investigates the heart's energy dynamics during acute heart failure (HF) to understand what happens during decompensation, which is when the heart can't pump effectively.
- It involved 50 patients with decompensated HF, measuring intracardiac energy loss (EL) using echo-vector flow mapping at both admission and discharge, comparing results with 40 stable patients who do not have HF.
- Findings showed that energy loss in the left ventricle increased significantly in decompensated HF cases compared to compensated ones, indicating energy inefficiency in the heart, especially among patients with preserved ejection fraction.
Article Synopsis
- The study focused on how different settings of cryoballoon ablation affect the size of frozen lesions in porcine hearts, particularly examining application duration and push-up technique.
- Results showed that longer application durations (at least 150 seconds) and the push-up technique (especially at 20 seconds post-freezing) significantly increase lesion size.
- Interestingly, the absence of laminar flow didn't lead to larger lesions, even though it resulted in lower balloon temperatures.
Reliable focal and rotational activations in CARTOFINDER mapping using the OctaRay catheter.
J Cardiovasc Electrophysiol
February 2024
Article Synopsis
- * OctaRay identified more focal and rotational activation sites than PentaRay, but had lower reproducibility and stability rates for these activations after pulmonary vein isolation in persistent AF patients.
- * Ultimately, the OctaRay catheter was found to provide high-resolution and reliable identification of focal and rotational activations, which are associated with shorter AF-cycle lengths and increased activation frequency.
Article Synopsis
- The study aimed to investigate the relationship between intracardiac dynamics during atrial fibrillation (AF) in patients with heart failure (HF) using echo-vector flow mapping.
- 76 patients were categorized into high and low NT-proBNP groups based on their serum levels, which helped assess energy loss during AF and sinus rhythms.
- Results showed that the high NT-proBNP group had significantly greater energy loss during AF, but this improved after restoring sinus rhythm, indicating a link between energy inefficiency and serum NT-proBNP levels.
A new meal tolerance test (MTT) using a 75 g glucose- and high fat-containing meal was applied to classify glucose intolerance in morbidly obese patients. According to the MTT data, the concordance rate of diagnosis was 82.5% compared to the 75 g oral glucose tolerance test (OGTT) in patients with normal glucose tolerance (NGT, n = 40).
View Article and Find Full Text PDFIntroduction: Various types of skin lesions with pruritus have been reported in participants of Asian clinical trials on sodium-glucose cotransporter-2 (SGLT2) inhibitors. The aim of this study was to determine whether the diuretic effect of a SGLT2 inhibitor could modify skin hydration status in patients with type 2 diabetes mellitus.
Methods: A prospective, short-term, open-label, two-parallel-arm, pilot study was conducted.
Article Synopsis
- Mysterin is identified as a gene linked to fat storage and susceptibility to moyamoya disease (MMD).
- Some female Japanese patients with characteristics of partial lipodystrophy also showed MMD-like vascular issues, leading to the investigation of mysterin variants.
- A specific variant, p.R4810K, was found in two patients and may contribute to a higher risk of atherosclerotic lesions in those with familial partial lipodystrophy type 1 (FPLD1).
Aims: Atrial fibrillation (AF) increases the risk of thromboembolism, such as ischaemic stroke or systemic embolism (SE). The aim of this study was to investigate the relationship between left ventricular relative wall thickness (RWT) and the risk of thromboembolism in patients with non-valvular AF.
Methods And Results: The Fushimi AF Registry is a community-based prospective survey of the patients with AF in Japan.
Article Synopsis
- The report investigates the clinical characteristics of a 12-year-old girl and her mother diagnosed with partial lipodystrophy and Type A insulin resistance syndrome.
- Advanced imaging techniques and genetic analysis were employed to evaluate fat distribution and identify potential genetic mutations linked to their conditions.
- A novel mutation in the insulin receptor gene was found, potentially causing insulin receptor dysfunction, which may be related to their fat loss and associated symptoms, such as the girl's amenorrhea, which improved with increased fat mass during adolescence.
Article Synopsis
- Heart failure (HF) affects stroke and systemic embolism (SE) risk in atrial fibrillation (AF) patients, but the impact varies based on the type and severity of HF.
- A study involving 3,749 AF patients showed that while 26.9% had pre-existing HF, it didn't significantly increase the risk of stroke/SE; however, higher levels of B-type natriuretic peptide (BNP) did.
- The risk of stroke/SE significantly rose in the first 30 days after hospitalization for HF, suggesting that the timing of HF episodes plays a crucial role in stroke risk rather than stable HF conditions.
Article Synopsis
- The study examined the clinical outcomes of female Japanese patients with atrial fibrillation (AF), noting that women constituted 40% of participants in the Fushimi AF Registry.
- Female AF patients were older and more likely to have heart failure compared to their male counterparts, but previous stroke incidence was similar for both sexes.
- The findings indicated that being female did not increase the risk of thromboembolism, but was linked to a lower risk of intracranial hemorrhage and overall mortality.