A Continuous Registry of Medical Record, Patient Input, and Epidemiological Data of Patients With Ulcerative Colitis: a Multicentre, Prospective, Observational Clinical Registry Study in Japan.

Background: This registry aims to allow for a prospective non-interventional observational study of ulcerative colitis. This will facilitate monitoring of the current state of ulcerative colitis in Japan and improving the long-term disease course and adverse events associated with current treatment options.

Methods: Inclusion of patients from five centres in Japan is planned.

Optimal Transport System for Acute Ischemic Stroke Patients: A Cost-Effectiveness Analysis.

This study conducted cost utility analysis comparing 4 systems of transporting acute ischemic stroke patients in Hokkaido, Japan. Hypothetical patients were generated on a geographic information system, and their outcomes were estimated according to their transport time to hospitals administering tissue plasminogen activator and/or endovascular thrombectomy. The transport systems where a neurointerventionist traveled for earlier endovascular thrombectomy were most cost-effective in some rural areas, while direct transportation to comprehensive stroke centers was more cost-effective in other areas.

Effectiveness of Leakage Prevention System in Communicating Important Diagnostic Information.

In Japan, oversights of imaging or pathology examination results and diagnoses provided to patients have become a major problem because they affect patient prognosis. We have jointly developed and used the "Anti-Impact Information Leakage Prevention System (AiR)" since December 2019. This system works effectively because its introduction, which uses a data warehouse, has increased versatility and considerably improved the situation of confirmation and communication.

Consideration of Usefulness of Leakage Prevention System for Critical Diagnostic Information Transmission.

In our country, overlooking and failing to communicate the results of imaging examinations and pathological examinations to patients is a problem. This is because it affects the prognosis of the patients. With the introduction of this system, the situation improved within six months, so this system was useful.

Characteristics of Type-2 Diabetics Who are Prone to High-Cost Medical Care Expenses by Bayesian Network.

: This study aims to determine the characteristics of Type 2 diabetic patients who are more likely to cause high-cost medical expenses using the Bayesian network model. : The 2011-2015 receipt data of Iwamizawa city, Japan were collected from the National Health Insurance Database. From the record, we identified patients with Type 2 diabetes with the following items: age, gender, area, number of days provided medical services, number of diseases, number of medical examinations, annual healthcare expenditures, and the presence or absence of hospitalization.

Analysis of Factors Inhibiting the Dissemination of Telemedicine in Japan: Using the Interpretive Structural Modeling.

Telemedicine is not significantly spreading globally and large variations in its availability and use exist internationally. Although many factors already inhibit the dissemination of telemedicine, its complexly intertwined factors make it more difficult to solve this problem. This study aimed to analyze and visualize relationships among factors inhibiting the dissemination of telemedicine.

[Willingness to Acceptance for the Information Leakage of Medical Information Data Using the Contingent Valuation Method].

Appropriate information security measures are very important for today's highly computerized hospitals to maintain the trust from patients. If once the personal information leakage of medical information was occurred, the hospital could lose their trust that has built for long time so far. It is important for hospitals to know the impact of the leakage accident previously advance to decide the investment for information security.

[Examination of the Important Factor during Implementation of the Medical Equipment and Hospital Information System Using the Correlation Analysis].

During medical equipment and hospital information system implementation in small- and medium-sized hospitals, the system introduction often advances after system selection by the management. However, in reality, the requirements of the systems between the management and staff layers were different. Therefore, the system did not often satisfy staff demands, resulting in increased dissatisfaction of the staff for the system.

Are the recorded data of flash glucose monitoring systems influenced by radiological examinations?

The FreeStyle Libre Pro flash glucose monitoring system is easy to use in diabetes care. However, the influence of radiological examination on recorded data has not been reported. The sensor should be removed prior to examinations involving strong magnetic or electromagnetic radiation.

Isozyme-specific comprehensive characterization of transglutaminase-crosslinked substrates in kidney fibrosis.

Chronic kidney disease is characterized by prolonged decline in renal function, excessive accumulation of ECM, and progressive tissue fibrosis. Transglutaminase (TG) is a crosslinking enzyme that catalyzes the formation of covalent bonds between glutamine and lysine residues, and is involved in the induction of renal fibrosis via the stabilization of ECM and the activation of TGF-β1. Despite the accumulating evidences indicating that TG2 is a key enzyme in fibrosis, genetic knockout of TG2 reduced by only 50% the elevated protein crosslinking and fibrous protein in renal fibrosis model, whereas treatment with TG inhibitor almost completely reduced these levels.

Willingness to Pay for Elderly Tele-Care System Using Digital Terrestrial Broadcasting.

The aim of this research is to quantify individual willingness-to-pay (WTP) to test effectiveness of Digital terrestrial broadcasting elderly tele-care system.We used contingent valuation method (CVM) to estimate the WTP for this system among 400 citizens living in Japan. The median WTP for this services's monthly fee is estimated to be 431 JPY.

Global identification and analysis of isozyme-specific possible substrates crosslinked by transglutaminases using substrate peptides in mouse liver fibrosis.

The transglutaminase (TG) family comprises eight isozymes that form the isopeptide bonds between glutamine and lysine residues and contribute to the fibrotic diseases via crosslinking-mediated stabilization of ECM and the activation of TGF-β in several tissues. However, despite a growing body of evidence implicating TG2 as a key enzyme in fibrosis, the causative role of TG2 and the involvement of the other isozymes have not yet been fully elucidated. Therefore, here we clarified the distributions of TG isozymes and their in situ activities and identified the isozyme-specific possible substrates for both TG1 and TG2 using their substrate peptides in mouse fibrotic liver.