Neurofibrillary tangles and deposition of oxidative products in the brain in cases of myotonic dystrophy.

Myotonic dystrophy (MyD) is a neuromuscular degenerative disorder that is neuropathologically characterized by minor changes, such as the presence of neurofibrillary tangles (NFT), thalamic inclusions and functional brainstem lesions. In the current study, we conducted an immunohistochemical analysis to examine the distribution of NFT and formation of oxidative products in the brain specimens of 12 patients with MyD. Neurofibrillary tangles were found in the limbic system and/or the brainstem of all the cases examined but there were no senile plaques.

[Two cases of silicate urolithiasis].

Case 1: A 31-year-old woman with the chief complaint of right back pain was referred to our hospital. She was diagnosed with a right ureteral stone and it was delivered spontaneously after conservative medical therapy. The stone was found to consist of silicate by infrared spectrometry.