An immune pathological and ultrastructural skin analysis for rhododenol-induced leukoderma patients.

As reported in the mass media on July 2013, numerous consumers who had used the cosmetic ingredient containing rhododendrol (4-(4-hydroxyphenyl)-2-butanol, Trade name; rhododenol), which is a melanin inhibitor isolated from Acer nikoense Maxim, released from Kanebo Cosmetics Inc. (Tokyo, Japan) noticed leukoderma patches on their face, neck and hands. We have experienced 32 cases that developed leukoderma after using such cosmetics so far and skin biopsy samples in some cases were obtained from both leukoderma and pigmented lesions.

Bullous pyoderma gangrenosum: a case report and review of the published work.

Pyoderma gangrenosum (PG) is an ulcerative skin disorder characterized by neutrophilic infiltrations. PG is generally classified into four types: (i) ulcerative; (ii) pustular; (iii) bullous; and (iv) vegetative. Among them, bullous PG is known as a rare type.

Aberrant cytokeratin 7 expression of centrilobular hepatocytes: a clinicopathological study.

Aims: This study has attempted to elucidate the clinicopathological features of aberrant cytokeratin 7 (CK7) expression by centrilobular hepatocytes.

Methods And Results: A total of 113 liver biopsy specimens from patients with common non-neoplastic liver diseases, including hepatitis B or C, non-alcoholic steatohepatitis, alcoholic liver disease and other diseases were examined. In 56 specimens (49.

Therapeutic effects of tacrolimus ointment for refractory ocular surface inflammatory diseases.

Purpose: To investigate the therapeutic effects of topical tacrolimus ointment on refractory ocular surface inflammatory diseases.

Design: Retrospective interventional consecutive case series.

Participants: Ten consecutive patients with severe ocular surface inflammatory diseases who were suspected to be steroid responders (elevation of intraocular pressure [IOP]) or were refractory to standard steroid therapy were studied.