Publications by authors named "Yuiichi Arakaki"
Article Synopsis
- The study investigates HPH-15, a compound that activates AMPK, for its potential as a diabetes treatment, focusing on its ability to manage blood glucose levels and prevent complications.
- Researchers tested HPH-15's effects on glucose uptake and fat accumulation in different cell types and high-fat diet mice, comparing it to the established diabetes drug metformin.
- Results showed HPH-15 improved blood glucose levels and reduced fat accumulation more effectively than metformin, indicating it may be a promising therapeutic option for diabetes management.
Drug repurposing is a distinguished approach for drug development that saves a great deal of time and money. Based on our previous successful repurposing of a compound BMMP from anti-HIV-1 therapy to anti-cancer metastatic activity, we adopted the same techniques for repurposing benzimidazole derivatives considering MM-1 as a lead compound. An extensive structure-activity relationship (SAR) study afforded three promising compounds, MM-1d, MM-1h, and MM-1j, which inhibited cell migration in a similar fashion to BMMP.
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