Publications by authors named "Yuichirou Nasu"
Dysbiosis of the enteric microbiota causes gastrointestinal diseases, including colitis. The present study investigated the beneficial effect of Lactobacillus plantarum 06CC2 in experimental colitis in mice. An experimental colitis model in C57BL6 mice was induced using dextran sulfate sodium.
View Article and Find Full Text PDFExcessive fructose intake is a risk factor for gut symptoms in patients with inflammatory bowel disease, however, its effect on the intestinal tract has not been evaluated previously. The present study investigated the impact of a high‑fructose diet (HFD) on intestinal barrier function in mice with experimental colitis. C57/BL6 mice were provided with either a HFD or control diet and either plain drinking water or water containing 1% dextran sulfate sodium (DSS) for 2 weeks.
View Article and Find Full Text PDFArticle Synopsis
- Helicobacter pylori (Hp) eradication can enhance the quality of life (QOL) for patients with gastric symptoms, but this study focuses on QOL improvements regardless of symptoms.
- Conducted over 15 institutions between September 2013 and December 2014, the study evaluated 165 Hp-infected patients before and after treatment using health surveys.
- Results showed that successful eradication of Hp led to significant improvements in both mental and physical health scores, particularly for those with initially low QOL before treatment, indicating that Hp eradication benefits a broad range of patients, not just those with noticeable symptoms.
Background: Apoptosis inhibitor of macrophages (AIM) was initially identified as an apoptosis inhibitor that supports the survival of macrophages against various apoptosis-inducing stimuli, and AIM produced by macrophages may contribute to the pathogenesis of inflammatory bowel diseases (IBDs). However, there have been no reports on the kinetics of AIM in IBD and the impact of AIM on the pathogenesis of IBD. In this study, we aimed to investigate the diagnostic utility of levels of AIM and their correlation with the activity of Crohn's disease (CD) and IBD.
View Article and Find Full Text PDFBackground And Study Aims: Although endoscopic submucosal dissection (ESD) is an established therapy for colon neoplasms including laterally spreading tumors (LSTs), its application to advanced fibrotic lesions is very difficult owing to the thin walls of the large intestine. We examined the ability of preoperative endoscopic ultrasonography (EUS) to predict lesion fibrosis in patients undergoing colorectal ESD.
Patients And Methods: From 2009 to 2013, 58 LSTs were evaluated retrospectively with EUS and treated using colorectal ESD.