Publications by authors named "Yuichiro Kiko"

Lung cancer remains a leading cause of global cancer‑related deaths, therefore the identification of prognostic factors for lung cancer is critical. Casein kinase 2 alpha (CK2α) is one of the driver kinases in various cancers, and it was previously demonstrated that CK2α localization was associated with a poor prognosis in invasive breast cancer. In the present study, the importance of CK2α in the nucleolus was explored as a potential prognostic marker for surgically resected early‑stage lung adenocarcinoma.

View Article and Find Full Text PDF

Drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe drug reaction characterized by skin rash, organ involvement, lymph node swelling, eosinophilia, and atypical lymphocytosis, with myocarditis being a rare but potentially fatal complication. It has been reported that in patients with cardiac involvement due to DRESS, older age and shorter periods between offending drug exposure and symptom onset are associated with mortality. We report a case of fatal DRESS-associated myocarditis in a young woman, occurring one month after drug exposure, despite intensive immunosuppressive therapy.

View Article and Find Full Text PDF
Article Synopsis
  • The study aims to identify genetic biomarkers that can help differentiate between ovarian serous carcinoma (OSC) and ovarian clear cell carcinoma (OCCC), two distinct types of epithelial ovarian cancer with different characteristics.
  • Researchers analyzed RNA from 57 surgical specimens of EOC patients using DNA microarray technology to find gene expression differences between the two cancer types.
  • They identified 10 candidate genes that were up-regulated in OCCC compared to OSC, suggesting these genes could serve as effective diagnostic markers and may provide insights into the distinct behaviors of these carcinomas, including OCCC's resistance to chemotherapy.
View Article and Find Full Text PDF
Article Synopsis
  • * An 80-year-old man exhibited symptoms like new headaches and jaw pain, and was ultimately diagnosed with TA, but treatment with high-dose steroids did not alleviate his severe gastrointestinal symptoms.
  • * While a new medication helped reduce some of his digestive issues, unfortunately, the patient died due to intestinal perforation, emphasizing the need for thorough investigation of gastrointestinal symptoms in similar patients.
View Article and Find Full Text PDF
Article Synopsis
  • A patient with previously diagnosed invasive ductal carcinoma of the breast underwent surgery and received Tamoxifen as treatment.
  • Four years later, she experienced irregular genital bleeding and was diagnosed with uterine metastasis of the breast cancer.
  • She began a new treatment regimen with aromatase inhibitors and CDK4/6 inhibitors and has been progression-free for 5 months.
View Article and Find Full Text PDF

Type B insulin resistance syndrome (TBIR) is a rare autoimmune disease characterised by autoantibodies targeting insulin receptors. TBIR is often complicated by systemic lupus erythematosus (SLE). We describe the case of a 59-year-old Japanese man with TBIR complicated with lupus nephritis (LN), who presented with nephrotic syndrome and severe hypoglycaemia.

View Article and Find Full Text PDF

Porto-sinusoidal vascular liver disease (PSVD) is a disorder that can cause portal hypertension without liver cirrhosis. TAFRO syndrome is a systemic inflammatory disorder with a background of immunological abnormalities. We report a case of TAFRO syndrome complicated by PSVD with portal hypertension.

View Article and Find Full Text PDF

Endoscopic hilar multiple stenting is challenging. A 68-year-old patient had self-expandable metallic stents (SEMSs) inserted for unresectable hilar malignant biliary obstruction. After the SEMSs were inserted into the left hepatic duct and bile duct branch of segment (B) 6, a new SEMS with a wide mesh and slim delivery system was inserted into the right anterior hepatic duct.

View Article and Find Full Text PDF

An ependymoma of the sella turcica and the suprasellar region has been described by only 10 reports in the available literature. We describe similar pathology in a 70-year-old woman who presented with dementia and visual disturbance. Magnetic resonance imaging with gadolinium revealed a mixed contrast-enhanced lesion(maximum diameter 3.

View Article and Find Full Text PDF

Overexpression of the ubiquitous protein kinase, CK2α, has been reported in various human cancers. Here, we demonstrate that nuclear and nucleolar CK2α localization in invasive ductal carcinomas of the breast is a reliable predictor of poor prognosis. Cellular localization of CK2α in nuclei and nucleoli was analyzed immunohistochemically using surgical tissue blocks from 112 patients, who had undergone surgery without neoadjuvant chemotherapy.

View Article and Find Full Text PDF

Double functional pituitary adenomas are rare, and only a few cases of excessive clinical symptoms of both adrenocorticotropic hormone(ACTH)and growth hormone(GH)have been reported. We herein report a case of symptomatic ACTH-and GH-producing double pituitary adenomas, which were discretely located within the same pituitary gland. A 38-year-old woman presented with general malaise, facial and lower limb edema, unexplained weight gain, facial redness, acne, and nasal enlargement.

View Article and Find Full Text PDF
Article Synopsis
  • Neuroendocrine ductal carcinoma in situ (NE-DCIS) is a rare subtype of ductal carcinoma in situ (DCIS) not typically covered in standard breast cancer classifications, first noted as an unusual variant in the WHO classification from 2012.
  • The main symptom of NE-DCIS is hemorrhagic nipple discharge, and its histological features include solid growth patterns with unique cell shapes that suggest low malignancy but are associated with a poor overall prognosis.
  • This report presents a second confirmed case of NE-DCIS diagnosed simultaneously in both breasts, highlighting its rarity and the associated symptoms observed at the patient’s outpatient visit.
View Article and Find Full Text PDF
Article Synopsis
  • An 84-year-old woman was discovered to have an asymmetric density in her breast through mammography, which led to the identification of a small cyst that later increased in size and developed solid components.
  • A core needle biopsy confirmed the presence of intracystic papillary carcinoma, prompting the patient to undergo a partial mastectomy and sentinel lymph node biopsy.
  • The histopathological analysis showed the cancerous growth was encapsulated and classified as a non-invasive carcinoma, indicating a positive prognosis for the patient.
View Article and Find Full Text PDF

Mammary carcinoma with osteoclast-like giant cells is uncommon, and its onset mechanism and malignancy are unknown. We report a case of mammary carcinoma with osteoclast-like giant cells. A 41-year-old woman noticed a lump in her left breast.

View Article and Find Full Text PDF

Acinar cell cystadenocarcinoma is a rare malignant epithelial neoplasm of the pancreas with a diffusely cystic, gross architecture in which the cysts are lined with neoplastic epithelial cells that demonstrate evidence of pancreatic exocrine enzyme production. This is the 10th case that has been reported in the literature. A 77-year-old male complaining of left hypochondrial pain was referred to our hospital for treatment of a pancreatic tumor.

View Article and Find Full Text PDF
Article Synopsis
  • MCP-1 enhances the progression of ovarian cancer by increasing the invasion and adhesion of SKOV-3 cells, a type of ovarian cancer cell line.
  • Experiments showed that treating SKOV-3 cells with MCP-1 significantly boosted their migration and attachment compared to untreated cells, with CCR2 playing a key role in this process.
  • The findings suggest that targeting MCP-1 could offer a new therapeutic approach for treating ovarian cancer, as blocking its receptor CCR2 reduced the aggressive behavior of the cancer cells.
View Article and Find Full Text PDF