Publications by Yuichi Sugiyam

Publications by authors named "Yuichi Sugiyam"

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Analysis of Nonlinear Pharmacokinetics of a Highly Albumin-Bound Compound: Contribution of Albumin-Mediated Hepatic Uptake Mechanism.

Yukina Fukuchi Kota Toshimoto Takanori Mori Keisuke Kakimoto Yoshifusa Tobe Yuichi Sugiyam

J Pharm Sci

September 2017

The cause of nonlinear pharmacokinetics (PK) (more than dose-proportional increase in exposure) of a urea derivative under development (compound A: anionic compound [pKa: 4.4]; LogP: 6.5; and plasma protein binding: 99.

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