Dexmedetomidine Pretreatment of Neuronal Cells Has Protective Effect Against Cell Death During Oxygen-glucose Deprivation/Reoxygenation, Based on IGF-1 Production.

Objective: Insulin-like growth factor 1 (IGF-1) protects neuronal-cell damage by ischemia. Although neuronal cells have been reported to produce IGF-1, the molecular mechanisms remains obscure. Dexmedetomidine (DEX) protects neuronal cells from ischemic damage.

Effect of Propofol on the Production of Inflammatory Cytokines by Human Polarized Macrophages.

Macrophages are key immune system cells involved in inflammatory processes. Classically activated (M1) macrophages are characterized by strong antimicrobicidal properties, whereas alternatively activated (M2) macrophages are involved in wound healing. Severe inflammation can induce postoperative complications during the perioperative period.

Successful use of femoral nerve block with dexmedetomidine for fracture fixation of an intracapsular fracture of the femoral neck in a patient with severe aortic stenosis: a case report.

We described a case in which femoral nerve block (FNB) and lateral femoral cutaneous nerve block (LFCNB) with dexmedetomidine (DEX) was useful for open reduction and internal fixation (ORIF) of a femoral neck fracture in a patient with severe aortic stenosis. Cardiac surgery had been recommended but was declined by the patient. Thus, ORIF was selected because of the patient's concomitant severe aortic stenosis.

Atypical gaze patterns in children and adults with autism spectrum disorders dissociated from developmental changes in gaze behaviour.

Eye tracking has been used to investigate gaze behaviours in individuals with autism spectrum disorder (ASD). However, traditional analysis has yet to find behavioural characteristics shared by both children and adults with ASD. To distinguish core ASD gaze behaviours from those that change with development, we examined temporo-spatial gaze patterns in children and adults with and without ASD while they viewed video clips.