Publications by authors named "Yui Ueda"
Article Synopsis
- Researchers investigated whether SARS-CoV-2 RNA can be found on the skin of COVID-19 patients by analyzing skin surface lipids (SSLs) collected from their faces.
- Using RT-PCR, they found that 84.6% of samples tested positive within 5 days of symptom onset, while only 30.4% tested positive between 6-10 days.
- The study also revealed an increase in specific genes related to the immune response in the skin samples, highlighting a new method for detecting the virus and studying its impact on human health non-invasively.
Recent findings in glycobiology revealed direct evidence of the involvement of oligosaccharide changes in human diseases, including liver diseases. Fucosylation describes the attachment of a fucose residue to a glycan or glycolipid. We demonstrated that fucosylated proteins are useful serum biomarkers for nonalcoholic fatty liver disease.
View Article and Find Full Text PDFmRNAs in skin surface lipids unveiled atopic dermatitis at 1 month.
J Eur Acad Dermatol Venereol
July 2023
Background: The molecular pathogenesis of atopic dermatitis (AD), presenting skin barrier dysfunction and abnormal inflammations around 1-2 months, is unreported.
Objective: We aimed to examine the molecular pathogenesis of very early-onset AD by skin surface lipid-RNA (SSL-RNA) using a non-invasive technology in infants aged 1 and 2 months from a prospective cohort.
Methods: We collected sebum by oil-blotting film of infants aged 1 and 2 months and analysed RNAs in their sebum.
Article Synopsis
- Non-invasive collection of mRNA from skin surface lipids (SSLs) offers insights into skin health and diseases by analyzing the genetic material found in the skin's natural oils.
- Research shows that human mRNAs are protected in SSLs, particularly from sebaceous glands, epidermis, and hair follicles, making them viable for study.
- In patients with atopic dermatitis, there are notable changes in gene expression related to inflammation and skin function, highlighting the potential of SSL-RNA analysis for better understanding skin conditions.
Aim: We identified Mac-2 (galectin-3) binding protein (Mac-2bp) as a novel diagnostic and liver fibrosis predicting biomarker for nonalcoholic steatohepatitis in humans. In mouse models, there are no serum biomarkers predicting liver disease severity. In this study, we developed a mouse Mac-2bp enzyme-linked immunosorbent assay (ELISA) system and determined its efficacy for predicting the severity of liver disease in mouse models, especially in non-alcoholic fatty liver disease (NAFLD) models.
View Article and Find Full Text PDFDrastic changes occur during the formation of the intestinal loop (IL), including elongation, physiological umbilical herniation (PUH), and midgut rotation. Fifty-four sets of magnetic resonance images of embryos between Carnegie stage (CS) 14 and CS 23 were used to reconstruct embryonic digestive tract in three dimensions in the Amira program. Elongation, PUH, and rotation were quantified in relation to the proximal part of the superior mesenteric artery (SMA), designated as the origin.
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