Publications by authors named "Yui Okada"
Article Synopsis
- The study evaluates how well next-generation sequencing (NGS) works for detecting RET proto-oncogene changes in thyroid cancer tissue samples from Japanese hospitals.
- Factors like sample age, processing methods, and DNA/RNA quality were analyzed to determine their impact on NGS success rates, which were found to be high overall (90% for DNA, 93% for RNA).
- Key findings highlighted that newer samples and specific fixation conditions improved NGS success, and the quality of extracted nucleic acids from older samples (≥3 years) was crucial for reliable results.
To provide a real-world snapshot of the clinical profile, management, and patient-reported outcomes (PRO) for advanced medullary and papillary thyroid cancer prior to the availability of rearranged during transfection (RET) inhibitors in Japan. Physicians completed patient-record forms for eligible patients seen during routine clinical practice. Physicians were also surveyed about their routine practice and patients were asked to provide PRO data.
View Article and Find Full Text PDFMGB polyamide-oligonucleotide conjugates - with linked MGB polyamides at the 2-exocyclic amino group of a guanine base using aminoalkyl linkers were synthesized and evaluated in terms of binding affinity for complementary DNA containing the MGB polyamide binding sequence using and CD analyses. The MGB polyamides comprised pyrrole polyamides (Py- and Py-), which possess binding affinity for A-T base pairs, and imidazole (Im-) and pyrrole--imidazole (Py--Im-) polyamide hairpin motifs, which possess binding affinity for C-G base pairs. It was found that the stability of modified dsDNA was greatly influenced by the linker length.
View Article and Find Full Text PDFBackground: The multikinase inhibitors (MKIs) sorafenib, lenvatinib, and vandetanib are approved for advanced thyroid cancer (TC) in Japan. How sequential treatment with MKIs is conducted in Japanese clinical practice is unknown.
Methods: This retrospective observational cohort study used a Japanese administrative claims database (April 2008-September 2021).
The singlet open-shell character and antiaromaticity are intriguing features in π-conjugated carbocycles. These two exhibit similar chemical and physical properties. However, they rarely coexist in the same molecule.
View Article and Find Full Text PDFUnderstanding the structure-property relationships in antiaromatic molecules is crucial for controlling their electronic properties and designing new organic optoelectronic materials. Dibenzo[ a, f]pentalene, a structural isomer of dibenzopentalene, displays open-shell and antiaromatic character harmonization, which is not shared by the well-known isomer, dibenzo[ a, e]pentalene. The next questions of interest concern the topological effects of the π-extension on the harmonization of the open-shell and antiaromatic character in the dibenzo[ a, f]pentalene π-system.
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- Venous thromboembolic events (VTE) are a common concern after total knee arthroplasty (TKA), especially in low-risk patients, and the study evaluates the effectiveness of mechanical VTE prophylaxis in these individuals.
- A retrospective analysis was conducted on low-risk TKA patients receiving different types of anesthesia to assess the occurrence of deep venous thrombosis (DVT) or pulmonary embolism (PE) during their recovery.
- The results showed no instances of clinically significant DVT or PE, suggesting that brief mechanical VTE prophylaxis is adequate for low-risk patients who can mobilize quickly post-surgery.
Mesityl derivatives of the unknown dibenzopentalene isomer dibenzo[a,f]pentalene were synthesized. The molecular geometry and physical properties of dibenzo[a,f]pentalene were investigated. Dibenzo[a,f]pentalene combines a large antiaromatic and appreciable singlet open-shell character, properties not shared by well-known isomer dibenzo[a,e]pentalene.
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- * Mice consuming resveratrol showed significantly reduced allergy symptoms, including lower production of IgE antibodies and less severe immune responses following allergy sensitization.
- * The study suggests that resveratrol may work by inhibiting the maturation of dendritic cells and altering T cell activation pathways, providing insight into its possible therapeutic role against food allergies.