Publications by authors named "Yui Natsume"
Introduction: This study was conducted to evaluate the population pharmacokinetics of prophylactic cefmetazole sodium (CMZ) based on the serum concentrations and establish a pharmacodynamics target concentration exceeding the minimum inhibitory concentration (MIC) to design the re-dosing interval.
Methods: Serum (n = 362) samples from 107 individuals were analyzed using a nonlinear mixed-effects model. The pharmacodynamics index obtained was regarded as the probability of maintaining CMZ serum trough exceeding the minimal inhibitory concentration (MIC) of 2 mg/L.
Article Synopsis
- The study aimed to analyze how cefazolin (CFZ) behaves in the body—specifically in serum and hip joint tissues—during total hip replacement surgery to guide effective dosing practices.
- Researchers used data from 249 serum and 125 hip joint capsule samples to create a two-compartment model, estimating key pharmacokinetic parameters (like clearance and volume of distribution).
- The results indicated that CFZ levels exceed the minimum inhibitory concentration (MIC) needed to combat MSSA infection in both serum and hip joint capsule tissues shortly after administration, emphasizing the need for individualized dosing plans based on these findings.