Publications by authors named "Yui Kimura"

A stray cat, an intact female Japanese domestic shorthair cat of unknown age (suspected to be a young adult), was rescued. The cat was lethargic and thin and had marked skin fragility, delayed wound healing without skin hyperextensibility, and hind limb proprioceptive ataxia and paresis. Survey radiography, computed tomography, and magnetic resonance imaging revealed congenital vertebral anomalies, including thoracolumbar transitional vertebrae, scoliosis resulting from a thoracic lateral wedge-shaped vertebra, and a kinked tail, and a dilated spinal cord central canal.

View Article and Find Full Text PDF

Objective: To evaluate the intraocular pressure (IOP)-lowering effect based on the number of ingredients and survival rate due to adverse reactions of brinzolamide (1%)/brimonidine (0.1%) fixed combination (BBFC).

Methods And Analysis: Among 424 patients newly administered BBFC from June 2020 to May 2021, 406 were retrospectively evaluated for adverse reactions and 299 were evaluated for the IOP-lowering effect of BBFC.

View Article and Find Full Text PDF
Article Synopsis
  • - Intracranial germ cell tumors (IGCTs) are rare brain tumors mostly affecting children and adolescents, especially in East Asian populations, and this study investigates their genetic background in a Japanese cohort.
  • - A specific genetic variant (rs3831846), a 4-bp deletion near the BAK1 gene, is linked to an increased risk of developing IGCTs, as shown by a genome-wide association study comparing 133 patients to 762 controls.
  • - The findings indicate that variants associated with testicular germ cell tumors in Europeans also show similar effects in Japanese IGCT patients, highlighting a shared genetic vulnerability across different populations and types of germ cell tumors.
View Article and Find Full Text PDF

Purpose: To investigate the effect of microincision vitreous surgery (MIVS) on intraocular pressure (IOP) control in glaucomatous eyes with functional filtering bleb.

Methods: We enrolled 18 patients (15 males; median age, 73 years) who previously had filtering surgery and underwent MIVS with functional filtering bleb. Kaplan-Meier method was used to calculate the survival rate with defined the failure as when more number of preoperative antiglaucoma medication was started or additional glaucoma surgery including bleb revisions were performed, and IOP increase of 20% (criteria 1) and 30% (criteria 2) from preoperative levels after 2 weeks of MIVS.

View Article and Find Full Text PDF
Article Synopsis
  • Atypical Burkitt leukemia/lymphoma (preBLL) has distinct molecular features that set it apart from classical Burkitt lymphoma (BL), particularly in their genetic mutations and translocation patterns.
  • A case study of an infant with preBLL revealed a mix of characteristics from both preBLL and classical BL, differing in immunophenotyping and genetic mutations.
  • The findings suggest that not all preBLL cases are easily distinguishable, highlighting the need for more research to better understand the variations within preBLL.
View Article and Find Full Text PDF
Article Synopsis
  • Atypical teratoid/rhabdoid tumor (AT/RT) is a rare and serious brain tumor that mostly affects young kids and is hard to treat.
  • Researchers created a special cell line from a patient's AT/RT tumor to test different cancer drugs and found that bortezomib, along with some other drugs, worked really well against these cells.
  • They discovered that using bortezomib together with another drug called panobinostat could be a promising way to treat AT/RT more effectively.
View Article and Find Full Text PDF

Allogeneic hematopoietic stem cell transplantation (HSCT) is performed as a curative treatment for children with nonmalignant diseases, such as bone marrow failure syndromes and primary immunodeficiencies. Because graft-versus-host-disease (GVHD) is a major factor affecting survival probability and quality of life after HSCT, the availability of HLA-matched donors restricts the application of HSCT. Recently, HSCT with post-transplantation cyclophosphamide (PTCy) has emerged as a potent method to prevent GVHD after HSCT from HLA-haploidentical donors, and some studies have suggested the safety of PTCy-HSCT for nonmalignant diseases.

View Article and Find Full Text PDF
Article Synopsis
  • * A total of 30 *spp.* and 23 *spp.* isolates were tested for resistance to 10 antimicrobials, with a significantly higher resistance rate found in *spp.* (34.8%) compared to *spp.* (0%).
  • * Resistance was linked to specific genetic factors, with several strains exhibiting common sequence types, suggesting the need for strict infection control measures in veterinary settings to curb the spread of these resistant bacteria.
View Article and Find Full Text PDF

We investigated the prevalence of virulence factors and antimicrobial resistance among 67 Acinetobacter spp. isolates, consisting of 21 Acinetobacter baumannii and 46 non-baumannii Acinetobacter from companion animals. The PCR analysis showed that the most prevalent virulence gene was afa/draBC (29.

View Article and Find Full Text PDF

Purpose: The aim of this study was to assess the in vitro efficacy of candidate antimicrobials against extended-spectrum β-lactamase (ESBL)-producing isolates of extraintestinal pathogenic Escherichia coli (ExPEC) from companion animals.

Methodology: A total of 90 ESBL-producing ExPEC isolates from dogs and cats were tested for susceptibility to 16 antimicrobials with the agar dilution method. We also identified the ESBLs and AmpC β-lactamases of these isolates with PCR and DNA sequencing.

View Article and Find Full Text PDF

Approximately 10% of patients with T1 colorectal cancer have lymph node metastases (LNM), requiring node dissection along with surgical resection. Patient gender was recently reported to affect the occurrence of LNM. The aim of the present study was to assess whether patient gender was predictive of LNM in T1 colorectal cancer.

View Article and Find Full Text PDF

IMP-1 type metallo-β-lactamase-producing (MBL-producing) Acinetobacter radioresistens was isolated from a dog with cystitis and a cat with conjunctivitis. The MBL-producing A. radioresistens isolates were resistant to all of the β-lactam antibiotics used in the sensitivity tests, but were susceptible to gentamicin, amikacin, and minocycline.

View Article and Find Full Text PDF

The emergence of antimicrobial resistance among Enterobacter spp., including resistance to extended-spectrum cephalosporins (ESC), is of great concern in both human and veterinary medicine. In this study, we investigated the prevalence of antimicrobial resistance among 60 isolates of Enterobacter spp.

View Article and Find Full Text PDF

Background/aim: Previous reports stated that pedunculated T1 colorectal carcinomas with 'head invasion' showed almost no nodal metastasis, requiring endoscopic treatment alone. However, clinically, some lesions develop nodal metastasis. We aimed to validate the necessity of distinguishing between 'pedunculated' and 'non-pedunculated' lesions, and also between 'head' and 'stalk' invasions.

View Article and Find Full Text PDF

The emergence of antimicrobial resistance in Klebsiella spp., including resistance to extended-spectrum cephalosporins (ESC) and fluoroquinolones, is of great concern in both human and veterinary medicine. In this study, we investigated the prevalence of antimicrobial resistance in a total of 103 Klebsiella spp.

View Article and Find Full Text PDF

Objectives: To investigate the clinical and epidemiologic characteristics of thromboembolism in Japanese children.

Methods: Clinical data of 77 patients with thromboembolism from a national tertiary pediatric care center were reviewed.

Results: Incidence of thromboembolism was calculated to be 15 per 10,000 hospital admissions.

View Article and Find Full Text PDF

Background And Aim: Recent advances in endoscopic technology have allowed many T1 colorectal carcinomas to be resected endoscopically with negative margins. However, the criteria for curative endoscopic resection remain unclear. We aimed to identify risk factors for nodal metastasis in T1 carcinoma patients and hence establish the indication for additional surgery with lymph node dissection.

View Article and Find Full Text PDF

Purpose: Submucosal invasion depth (SID) in colorectal carcinoma (CRC) is an important factor in estimating risk of lymph node metastasis, but can be difficult to measure, leading to inadequate or over-extensive treatment. Here, we aimed to clarify the practical aspects of measuring SID in T1 CRC.

Methods: We investigated 568 T1 CRCs that were resected surgically at our hospital from April 2001 to December 2013, and relationships between SID and clinicopathological factors, including the means of measurement, lesion morphology, and lymph node metastasis.

View Article and Find Full Text PDF

Mycoplasma pneumoniae causes pneumonia, tracheobronchitis, pharyngitis, and asthma in humans. The pathogenesis of M. pneumoniae infection is attributed to excessive immune responses.

View Article and Find Full Text PDF

Brucella canis, a facultative intracellular pathogen, is the causative agent of canine brucellosis. The diagnosis of canine brucellosis is based on bacteriological examination and serological methods, including agglutination and gel diffusion tests. In this study, four recombinant antigens, heat shock protein 60, rhizopine-binding protein, Cu-Zn superoxide dismutase, and hypothetical protein (Ag 4), were constructed.

View Article and Find Full Text PDF

Hot springs are the most common infectious source of Legionella pneumophila in Japan. However, little is known about the association between L. pneumophila and environmental waters other than hot springs.

View Article and Find Full Text PDF

Synopsis of recent research by authors named "Yui Kimura"

  • - Yui Kimura's recent research focuses primarily on veterinary medicine, ocular health, and cancer genetics, contributing significant findings related to feline health, glaucoma treatments, and mutations linked to specific tumors.
  • - In the veterinary domain, Kimura identified a case of malnutrition-induced skin syndrome in a cat with congenital deformities and investigated antimicrobial resistance in various bacterial isolates from companion animals.
  • - The author also conducted pivotal studies in ophthalmology, assessing the effects of brinzolamide and brimonidine on intraocular pressure and exploring genetic features in cancers like intracranial germ cell tumors and atypical teratoid/rhabdoid tumors, highlighting the need for innovative treatment strategies.

A PHP Error was encountered

Severity: Warning

Message: fopen(/var/lib/php/sessions/ci_sessiongghucsksuknuqfe5njj94p2md0s9652m): Failed to open stream: No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 177

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: session_start(): Failed to read session data: user (path: /var/lib/php/sessions)

Filename: Session/Session.php

Line Number: 137

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once