Genome-Wide Analysis of the Gene Family in Potato and Functional Verification of Under Drought Stress.

The JASMONATE-ZIM DOMAIN (JAZ) repressors are crucial proteins in the jasmonic acid signaling pathway that play a significant role in plant growth, development and response to abiotic stress (such as drought, heat, salinity, and low temperature). In this study, we identified 26 potato genes and classified the corresponding predicted proteins into five subfamilies. All potato JAZ proteins exhibited the expected conserved TIFY (TIF[F/Y] XG) and JAZ domains.

Faberidilactone A, a Sesquiterpene Dimer, Inhibits Hepatocellular Carcinoma Progression Through Apoptosis, Ferroptosis, and Anti-Metastatic Mechanisms.

Cancer remains a significant global public health challenge, with hepatocellular carcinoma (HCC) ranking among the top five malignancies in terms of mortality. Faberidilactone A, a sesquiterpenoid dimer isolated from , exhibits potent cytotoxicity against various human tumor cell lines and demonstrates remarkable antitumor potential. In vitro studies using HepG2 cells revealed that faberidilactone A induces apoptosis and ferroptosis, causes cell cycle arrest, enhances the production of intracellular reactive oxygen species (ROS), and disrupts mitochondrial function.

Application of separation and configuration identification of the four tetrabenazine stereoisomers in determining their pharmacokinetics.

Tetrabenazine (TBZ) is used in the treatment of psychiatric diseases, and it works by inhibiting vesicular monoamine transporter 2 (VMAT2) protein to exert a curative effect. TBZ is administered as the mixture of stereoisomers in clinical treatment. TBZ has two chiral centers, and therefore, it has four stereoisomers, and this greatly makes it difficult to separate the stereoisomers and to identify their configurations because of their high susceptibility to structural transformation.

Tuning charge transportation balance in quantum dot light emitting diodes by decreasing the mobility and conductivity of In-doped SnO nanocrystal electron transport layers.

The use of quantum sized SnO nanocrystals as the electron transportation layer (ETL) in quantum dot light-emitting diodes (QLEDs) has been demonstrated to be an effective method for improving device stability and eliminating the positive aging effect. However, compared to the commonly used 4,4'-bis(-carbazolyl)-1,1'-biphenyl (CBP) hole transportation layer (HTL), the quantum sized SnO nanocrystals usually possess a higher electron mobility and a higher conductivity, which results in the charge transport imbalance in QLEDs. Herein, In-doped SnO quantum-sized nanocrystals are synthesized by the ligand-assisted solvothermal method.

Preliminary quantitative analysis of renal sinus fat dysfunction in T2DM patients using MRI fat fraction and R2* mapping.

Purpose: To quantitatively analyze renal sinus fat (RSF) dysfunction in type 2 diabetes mellitus (T2DM) patients using magnetic resonance imaging (MRI) fat fraction (FF) and R2* mapping.

Methods: The inpatients who underwent 1.5 T MRI examination (including MRI FF and R2* mapping) of the abdomen from January 2017 to December 2023 were enrolled.

Clinical characteristics, surgical approaches, and prognosis of follicular and papillary thyroid cancer in children and adolescents: a retrospective cohort study.

Purpose: Follicular and papillary thyroid cancers are prevalent endocrine tumors in children and adolescents. This study seeks to highlight distinctions between papillary thyroid cancer  (PTC) and follicular thyroid cancer  (FTC) to inform subtype-specific guidelines.

Patients And Methods: Utilizing data from the SEER database, this study contrasts the clinical features, survival rates, causes of death, TNM staging, and surgical interventions for pediatric and adolescent patients diagnosed with PTC and FTC from 2000 to 2020.

Exceptional Suppression of the Self-Discharge Behavior of Supercapacitors by Precisely Tuning the Surface Assets of MXene by a Spontaneous Single-Atom Doping Strategy.

MXene-based supercapacitors (SCs) are widely regarded as promising energy storage devices. However, the inevitable and ignored self-discharge behavior of MXene-based SCs causes an unavoidable voltage decay and energy loss. Herein, the Ru single-atom doping strategy is used to fabricate a Ru-MXene film to modulate the surface properties of MXene, and the assembled Ru-MXene film-based SC showed a suppressed self-discharge behavior due to the simultaneously reduced activation-controlled and diffusion-controlled reactions.

Genome-Wide Identification and Drought-Responsive Functional Analysis of the Gene Family in Potato ( L.).

Glutathione S-transferases () play crucial roles in crop stress tolerance through protection against oxidative damage. In this study, we conducted genome-wide identification and expression analysis of the gene family in the autotetraploid potato cultivar Cooperative-88 (C88) using bioinformatic approaches. We identified 366 genes in the potato genome, which were classified into 10 subfamilies.

METTL3 stabilizes SERPINE2 via the m6A modification to drive the malignant progression of gastric signet ring cell carcinoma.

Background: Gastric signet ring cell carcinoma (GSRCC) is a highly lethal malignancy. Serpin family E member 2 (SERPINE2) is a pro-tumorigenic factor in cancer. Here, we sought to define the role of SERPINE2 in the pathogenesis of GSRCC.

Molten salt-mediated electrosynthesis of MoS nanosheet-supported Rh nanoclusters for highly efficient electrocatalytic hydrogen evolution.

We report the synthesis of MoS nanosheet-supported Rh nanoclusters a facile yet efficient molten salt electrolysis method followed by wet chemical reduction for electrocatalytic hydrogen evolution. In-depth study reveals that the uniform Rh nanoclusters on MoS nanosheets can shorten the electronic transport path, and effectively promote the hydrogen evolution reaction kinetics.

Synergistic Removal of Rare Earth Elements from Radioactive Molten Salt via Electrodeposition and Adsorption.

Recycling waste salt in the dry reprocessing of nuclear fuel and reducing electric energy consumption in the electrorefining process are crucial steps toward addressing significant challenges in this field. The present study proposes a novel approach to purify waste salt by selectively adsorbing excessive fission products using 5A molecular sieves (5A), based on the principles of electrorefining, with the ultimate aim of achieving sustainable development in nuclear fuel. First, Lutetium (Lu)-Bi alloy was synthesized through constant potential electrolysis in the LiCl-KCl-LuCl melt, resulting in a 90.

Enhancing Photovoltaically Preferred Orientation in Wide-Bandgap Perovskite for Efficient All-Perovskite Tandem Solar Cells.

Wide-bandgap perovskite solar cells (WBG PSCs) have promising applications in tandem devices yet suffer from low open-circuit voltages (Vs) and less stability. To address these issues, the study introduces multifunctional nicotinamide derivatives into WBG PSCs, leveraging the regulation on photovoltaically preferential orientation and optoelectronic properties via diverse functional groups, e.g.

SERS-based simplified analysis of paraquat in poisoning cases: Bypassing complicated pretreatment with antioxidant sensor.

Applying antioxidant coating materials to prepare surface-enhanced Raman spectroscopy (SERS) sensing substrates can effectively enhance the sensitivity and stability for the analysis of molecules. In this study, we have leveraged SERS to develop an innovative sensor for the swift identification of Paraquat (PQ), enabling on-site detection of this herbicide. The newly devised sensor distinguishes itself through its exceptional oxidation resistance.

Roles of blood monocytes carrying TREM2 mutation in pathogenesis of Alzheimer's disease and its therapeutic potential in APP/PS1 mice.

Introduction: The triggering receptor expressed on myeloid cells 2 (TREM2) arginine-47-histidine (R47H) mutation is a significant risk for Alzheimer's disease (AD) with unclear mechanisms. Previous studies focused on microglial amyloid-β (Aβ) phagocytosis with less attention on the impact of TREM2 mutation on blood monocytes.

Methods: Bone marrow transplantation (BMT) models were used to assess the contribution of blood monocytes carrying TREM2 mutation to AD.

Comprehensive Analysis of the OASTL Gene Family in Potato ( L.) and Its Expression Under Abiotic Stress.

O-acetylserine (thiol) lyase is a pivotal enzyme in plant cysteine biosynthesis, which is crucial for promoting plant growth, development, and resisting abiotic stress. However, the related studies on the potato OASTL gene family (StOASTL) have not been reported. In the present study, we identified 11 members of the StOASTL gene family, conducting a thorough analysis encompassing chromosome distribution, protein physicochemical properties, gene structure, protein-conserved motifs, and gene replication events.

Overexpression of in Potato Enhances Tolerance to Drought Stress.

Calcium-dependent protein kinases (CDPKs), which are activated by transient changes in the Ca concentration in plants, are important for various biological processes, such as growth, development, defense against biotic and abiotic stresses, and others. Mannitol is commonly used as an osmotic regulatory substance in culture medium or nutrient solutions to create water-deficit conditions. Here, we cloned the potato ( L.

Prospective analysis of the effects of mutation on local tumor progression and overall survival after radiofrequency ablation for colorectal liver metastases.

Objectives: To investigate the effects of mutation on local tumor progression (LTP) and overall survival (OS) after radiofrequency ablation (RFA) for colorectal liver metastases (CRLMs).

Methods: This prospective study consecutively enrolled patients with CRLM who underwent ultrasound-guided RFA between June 2020 and July 2022. mutation status was analyzed via the amplification refractory mutation system PCR method.

Spatial microenvironment enhanced photocatalytic reduction of uranyl ions under solar light irradiation.

Photocatalytic reduction of uranyl ions (UO) is an environmentally friendly, energy efficient, and highly effective method for uranium-containing wastewater treatment and uranium recovery. Herein, a novel photocatalytic material CH-8 @NNFO-4 with abundant oxygen vacancies was synthesize by growing Ca(OH) on the surface of Fe doped NaNbO in situ. The Ca(OH) synergizes with the oxygen vacancies, creating a microenvironment that narrows the bandgap and extends the light response range.

Deep learning radiomics based on contrast enhanced MRI for preoperatively predicting early recurrence in hepatocellular carcinoma after curative resection.

Purpose: To explore the role of deep learning (DL) and radiomics-based integrated approach based on contrast enhanced magnetic resonance imaging (CEMRI) for predicting early recurrence (ER) in hepatocellular carcinoma (HCC) patients after curative resection.

Methods: Total 165 HCC patients (ER, = 96 vs. non-early recurrence (NER), = 69) were retrospectively collected and divided into a training cohort ( = 132) and a validation cohort ( = 33).

Systemic immune-related spleen radiomics predict progression-free survival in patients with locally advanced cervical cancer underwent definitive chemoradiotherapy.

Purpose: Systemic immunity is essential for driving therapeutically induced antitumor immune responses, and the spleen may reflect alterations in systemic immunity. This study aimed to evaluate the predictive value of contrast-enhanced CT-based spleen radiomics for progression-free survival (PFS) in patients with locally advanced cervical cancer (LACC) who underwent definitive chemoradiotherapy (dCRT). Additionally, we investigated the role of spleen radiomics features and changes in spleen volume in assessing systemic immunity.

An unexpected retained metallic intraocular foreign body.

Purpose: This case report aims to describe a rare case of asymptomatic retained metallic intraocular foreign body (IOFB) in the retina with reduced full-field electroretinography (ff-ERG) in a Chinese woman.

Methods: This is a clinical investigation of a patient who unexpectedly presented with a metallic IOFB at the superior-temporal region of the left eye ring during a brain computed tomography.

Results: Her best-corrected visual acuity was 20/20 in both eyes.

Autoantibodies to BACE1 promote Aβ accumulation and neurodegeneration in Alzheimer's disease.

The profile of autoantibodies is dysregulated in patients with Alzheimer's disease (AD). Autoantibodies to beta-site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1) are present in human blood. This study aims to investigate the clinical relevance and pathophysiological roles of autoantibodies to BACE1 in AD.