Publications by authors named "Yuhsin Vivian Huang"
Background: Immune checkpoint inhibitors (ICIs) are successful in treating many cancers but may cause immune-related adverse events. ICI-mediated myocarditis has a high fatality rate with severe cardiovascular consequences. Targeted therapies for ICI myocarditis are currently limited.
View Article and Find Full Text PDFImmune checkpoint inhibitor (ICI)-mediated myocarditis is a rare but devastating side effect of cancer immunotherapy with up to 40% mortality and long-term cardiac issues such as arrhythmias and heart failure in affected patients. Recently, Axelrod et al. suggested an auto-antigen-driven mechanism as the immunological basis for this disease.
View Article and Find Full Text PDFArticle Synopsis
- - ICIs (Immune Checkpoint Inhibitors) in cancer treatment may lead to severe heart-related immune side effects.
- - Single-cell multi-omics are advanced methods that help identify and analyze different types of cells.
- - Utilizing multi-omics technology can reveal how ICI-induced myocarditis occurs and its underlying mechanisms.
Article Synopsis
- Immune checkpoint inhibitors (ICIs) are treatments that enhance the immune response against tumors but can lead to severe side effects like myocarditis, which has a high mortality rate.
- Researchers studied blood samples from 52 individuals, including those with autoimmune side effects from ICIs and healthy controls, using advanced techniques to identify specific immune cell changes related to ICI myocarditis.
- Findings revealed an increase in a specific type of immune cell, cytotoxic CD8 T effector cells, in patients with myocarditis, indicating a strong immune activation that could explain the condition's severity.